Radical Aromatic Substitution via Atom-Transfer Addition

通过原子转移加成进行自由基芳香取代

• 批准号: 9732600
• 负责人: Jeffrey Byers
• 金额: $ 13.93万
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9732600&HistoricalAwards=false
• 关键词: Radical; Aromatic; Substitution; via; Atom

Professor Jeffrey H. Byers, of the Department of Chemistry and Biochemistry at Middlebury College, is supported by a Research in Undergraduate Institutions award from the Organic and Macromolecular Chemistry Program for his studies of radical aromatic substitution via atom transfer addition. Professor Byers studies the reactions of aromatic and heteroaromatic substances with a variety of electrophilic radicals. The electronic nature of the aromatic ring is modified through the use of suitable protecting groups and through the formation of arene chromium tricarbonyl complexes, thus providing aromatic substrates reactive toward electron-rich radicals. Professor Byers is also exploring intramolecular reactions leading to the formation of mitocene and pyrrolizidine ring systems, common structural features of a range of biologically active compounds. Although organic molecules containing an unpaired electron (`radicals`) are often very reactive, they have until recently received comparatively little attention as potential participants in the synthesis of organic molecules. With the support of a Research in Undergraduate Institutions award from the Organic and Macromolecular Chemistry Program, Professor Jeffrey H. Byers, of the Department of Chemistry and Biochemistry at Middlebury College, explores a class of radical-forming reactions known as atom-transfer additions for their ability to facilitate the synthesis of aromatic compounds. Products potentially made accessible through the discovery and development of this chemistry include aryl acetic acids, a general class of compounds frequently used as analgesics and anti-inflammatory medications, as well as a variety of more complex structures representing common structural features of a range of biologically active compounds.

Jeffrey H.拜尔斯，化学系和 生物化学在明德学院，是由一项研究， 有机与高分子本科院校奖 化学计划，他的研究自由基芳香取代通过 原子转移加成 拜尔斯教授研究了 芳香族和杂芳香族物质与各种亲电 根的 芳环的电子性质通过以下方式被改变： 使用合适的保护基和通过形成芳烃 三羰基铬络合物，从而提供芳族底物 对富电子自由基有反应 拜尔斯教授也是 探索导致中新世形成的分子内反应 和吡咯里西啶环系统，一系列的共同结构特征， 生物活性化合物。 虽然含有不成对电子的有机分子（“自由基”） 通常非常被动，直到最近， 作为有机合成的潜在参与者， 分子。 在本科院校研究的支持下 有机和高分子化学计划奖，教授 杰弗里·H拜尔斯，化学和生物化学系， 米德尔伯里学院，探索一类激进的形成反应， 作为原子转移添加剂，因为它们能够促进合成 芳香族化合物。 产品可能通过 这种化学的发现和发展包括芳基乙酸， 常用作止痛剂的化合物的一般类别， 抗炎药物，以及各种更复杂的 代表一系列的共同结构特征的结构 生物活性化合物。