Mass Spectrometry and Computational Studies of Deprotonated Peptides and Amino Acid Amides

去质子化肽和氨基酸酰胺的质谱和计算研究

• 批准号: 0848470
• 负责人: Carolyn Cassady
• 金额: $ 47万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848470&HistoricalAwards=false
• 关键词: Mass; Spectrometry; Computational; Studies; Deprotonated

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program in the Division of Chemistry supports work by Professors Carolyn Cassady and David Dixon at the University of Alabama - Tuscaloosa aimed at enhanced understanding of the gas-phase chemistry of deprotonated amino acid amides and peptides, in order ultimately to provide new approaches to mass spectrometric structure elucidation supporting proteomics and related studies. Combined experimental and computational efforts will provide insight into fragmentation and thermodynamic properties. The work exposes a diverse group of both graduate and undergraduate students to important interdisciplinary research areas, providing them with tools that will prepare them to contribute to a wide range of chemical biology challenges. Both PIs have also been actively engaged in outreach activities, exposing large numbers of students to the powerful computational and analytical tools utilized in their laboratories.

该奖项是根据2009年美国复苏和再投资法案资助的（公法111-5）。化学系的分析和表面化学项目支持亚拉巴马-塔斯卡卢萨大学的Carolyn Cassady和大卫狄克逊教授的工作，旨在增强对去质子化氨基酸酰胺和肽的气相化学的理解，以最终提供支持蛋白质组学和相关研究的质谱结构解析的新方法。 结合实验和计算的努力，将提供洞察碎裂和热力学性质。 这项工作使研究生和本科生的多元化群体接触到重要的跨学科研究领域，为他们提供工具，使他们能够为各种化学生物学挑战做出贡献。 这两个PI还积极参与外展活动，使大量学生接触到他们实验室中使用的强大计算和分析工具。