Mass Spectrometry and Computational Studies of Deprotonated Peptides and Amino Acid Amides

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。化学系的分析和表面化学项目支持阿拉巴马大学塔斯卡卢萨分校的Carolyn Cassady教授和David Dixon教授的工作，旨在加强对去质子化氨基酸酰胺和肽的气相化学的理解，最终为支持蛋白质组学和相关研究的质谱结构解析提供新的方法。结合实验和计算的努力将提供洞察碎片和热力学性质。这项工作使研究生和本科生的不同群体接触到重要的跨学科研究领域，为他们提供工具，使他们准备好为广泛的化学生物学挑战做出贡献。两个pi也积极参与外联活动，使大量学生接触到实验室中使用的强大的计算和分析工具。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program in the Division of Chemistry supports work by Professors Carolyn Cassady and David Dixon at the University of Alabama - Tuscaloosa aimed at enhanced understanding of the gas-phase chemistry of deprotonated amino acid amides and peptides, in order ultimately to provide new approaches to mass spectrometric structure elucidation supporting proteomics and related studies. Combined experimental and computational efforts will provide insight into fragmentation and thermodynamic properties. The work exposes a diverse group of both graduate and undergraduate students to important interdisciplinary research areas, providing them with tools that will prepare them to contribute to a wide range of chemical biology challenges. Both PIs have also been actively engaged in outreach activities, exposing large numbers of students to the powerful computational and analytical tools utilized in their laboratories.