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MRI: Acquisition of a high performance matrix-assisted laser ionization dual time-of-flight (MALDI/TOF-TOF) mass spectrometer (MS)

MRI：购买高性能基质辅助激光电离双飞行时间 (MALDI/TOF-TOF) 质谱仪 (MS)

基本信息

批准号：
1726812
负责人：
Carolyn Cassady
金额：
$ 39.12万
依托单位：
University of Alabama Tuscaloosa
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2020-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726812&HistoricalAwards=false
关键词：
MRI Acquisition performance matrix assisted

项目摘要

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation Programs. Professor Carolyn Cassady from University of Alabama Tuscaloosa and colleagues Yuping Bao, Jason Bara, Marco Bonizzoni and Paul Rupar are acquiring a matrix assisted laser desorption/ionization time-of-flight mass spectrometer with collision induced dissociation (CID) capabilities (MALDI/TOF-TOF MS.) In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. MALDI TOF combines gentle ionization (ideal for producing intact ions of peptides, proteins, nucleic acids, carbohydrates, synthetic polymers, and other similarly sized species) with a detection mode that offers an excellent balance between sensitivity and accuracy across a wide mass range. This highly sensitive technique allows identification and determination of the structure of molecules in a complex mixture. The acquisition strengthens the research infrastructure at the university and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used in outreach activities, such as the annual Alabama Advanced Instrumental Techniques Colloquium (AITC), which exposes undergraduate students from throughout the region to state-of-the-art instrumentation. Students in an NSF Research experiences for Undergraduates (REU) program in chemistry and materials science also use the MALDI/TOF-TOF MS.This mass spectrometer enhances research and education at all levels. It aids researchers in developing techniques for the analysis and sequencing of acidic peptides using deprotonated ions and for characterizing structures, molecular weights and other properties of polymer-ionene hybrids. The MALDI/TOF-TOF MS is used to examine iron oxide nanoparticle platforms for a variety of biomolecules and polymers. The instrumentation is also used for characterizing host-guest complexes of hyperbranched polyelectrolytes and analyzing polyimines produced by anionic ring opening polymerizations.

该奖项由主要研究仪器（MRI）和化学研究仪器计划支持。来自亚拉巴马塔斯卡卢萨大学的Carolyn Cassady教授及其同事Yuping Bao，Jason Bara，Marco Bonizzoni和Paul Rupar正在获得具有碰撞诱导解离（CID）功能的基质辅助激光解吸/电离飞行时间质谱仪（MALDI/TOF-TOF MS）。一般来说，质谱（MS）是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。MALDI TOF结合了温和的离子化（非常适合产生肽、蛋白质、核酸、碳水化合物、合成聚合物和其他类似大小的物质的完整离子）和检测模式，在广泛的质量范围内提供灵敏度和准确度之间的出色平衡。这种高灵敏度的技术可以识别和确定复杂混合物中分子的结构。此次收购加强了大学和地区的研究基础设施。该仪器通过让不同的学生参与这种现代分析技术来扩大参与。它还用于外联活动，如年度亚拉巴马高级仪器技术研讨会（AITC），该研讨会使整个地区的本科生接触到最先进的仪器。 NSF化学和材料科学本科生研究经验（REU）项目的学生也使用MALDI/TOF-TOF MS。该质谱仪增强了各级研究和教育。它帮助研究人员开发使用去质子化离子分析和测序酸性肽的技术，以及表征聚合物-紫罗烯杂交物的结构，分子量和其他性质的技术。 MALDI/TOF-TOF MS用于检查氧化铁纳米颗粒平台的各种生物分子和聚合物。该仪器还用于表征超支化聚电解质的主客体复合物和分析由阴离子开环聚合产生的聚亚胺。