Assigning potential neurotransmitters and neuromodulators to identified local interneurons of the antennal lobe

昆虫的触角叶在结构组织和生理功能上与脊椎动物嗅球有许多惊人的相似之处，为构建合理的嗅觉信息处理通用模型做出了重要贡献。不同种类的局部中间神经元有助于处理、构建和空间表征触角叶中的嗅觉信息。在美洲大蠊中，我们发现了几种不同类型的局部中间神经元，它们具有不同的形态、突触和内在电生理特性，这意味着这些神经元在嗅觉系统中发挥着不同的功能。在这里，我们将分析不同局部中间神经元类型的潜在神经递质和神经调节剂的具体清单。虽然之前的研究已经调查了各种昆虫触角叶的神经化学组织，但这将是第一次将潜在神经活性物质的清单明确归类为不同的、功能不同的LN类型。

The insect antennal lobe, due to the many striking similarities in structural organization and physiological function with the vertebrate olfactory bulb, has contributed significantly to the construction of reasonable general models for olfactory information processing. A diverse population of local interneurons helps to process, structure and spatially represent olfactory information in antennal lobe. In Periplaneta americana we identified several types of local interneurons with distinct morphological, synaptic, and intrinsic electrophysiological properties, implying that these neurons serve distinct functions in the olfactory system. Here we will analyze the specific inventories of potential neurotransmitters and neuromodulators of distinct local interneuron types. While previous studies have investigated the neurochemical organization of the antennal lobe in various insect species, this will be the first time that the inventory of potentially neuroactive substances will be unequivocally assigned to the distinct, functionally different LN types.