NSF Minority Postdoctoral Fellowship for FY 2009

2009 财年 NSF 少数族裔博士后奖学金

• 批准号: 0905824
• 负责人: John Jones
• 金额: $ 18.9万
• 依托单位: Jones John M
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0905824&HistoricalAwards=false
• 关键词: NSF; Minority; Postdoctoral; Fellowship; FY

This action funds an NSF Minority Postdoctoral Research Fellowship for FY 2009 and is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to John M. Jones is "Characterizing chemokine receptors and their signaling complexes." The host institution for this research is the University of California San Diego under the sponsorship of Dr. Tracy Handel. Chemokines are small proteins that direct the movement of cells within the mammalian body by binding to chemokine receptors. Due to their biological importance, chemokine receptors and other related receptors are highly valued targets for biotechnology as well as in basic research. However, progress in understanding how chemokines work has been limited by difficulties in producing receptor in the laboratory. This project seek to overcome this difficulty by producing chemokine receptors in bacteria, which are commonly used to produce proteins. Being able to produce sufficient quantities of receptor will allow the pursuit of a variety of scientific experiments that otherwise would not be possible. This project is also studying how these receptors interact with other proteins within the cell, called a signaling complex, by using very sensitive techniques to determine what proteins are associating with the receptor in response to chemokine binding.Training objectives include mentoring and teaching the next generation of scientists. The complexity of this biological system promises a fruitful research area for years to come and provides for the involvement of undergraduate and graduate students who are attracted to research with practical and societal benefits.

该行动资助了2009财年NSF少数民族博士后研究奖学金，并根据2009年美国复苏和再投资法案（公法111-5）提供资金。该奖学金支持研究员在宿主实验室的研究和培训计划，并提出了扩大生物学参与的计划。本奖学金的研究和培训计划的标题是约翰M。琼斯是“表征趋化因子受体及其信号复合物。“这项研究的主办机构是加州圣地亚哥大学，由特雷西·汉德尔博士赞助。趋化因子是通过结合至趋化因子受体来指导哺乳动物体内细胞运动的小蛋白质。 由于它们的生物学重要性，趋化因子受体和其他相关受体是生物技术以及基础研究中高度重视的目标。然而，理解趋化因子如何工作的进展受到在实验室中产生受体的困难的限制。 该项目试图通过在细菌中产生趋化因子受体来克服这一困难，这些趋化因子受体通常用于产生蛋白质。 能够产生足够数量的受体将允许进行各种科学实验，否则将不可能。 该项目还研究这些受体如何与细胞内的其他蛋白质相互作用，称为信号复合物，通过使用非常敏感的技术来确定哪些蛋白质与受体结合以响应趋化因子结合。培训目标包括指导和教导下一代科学家。这个生物系统的复杂性，承诺在未来几年的一个富有成效的研究领域，并提供了本科生和研究生谁是吸引研究与实际和社会效益的参与。