Responsive Molecular Assemblies

响应性分子组装体

• 批准号: 0910845
• 负责人: Robin McCarley
• 金额: $ 48.5万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0910845&HistoricalAwards=false
• 关键词: Responsive; Molecular; Assemblies

The Analytical and Surface Chemistry Program of the Division of Chemistry at NSF will support the research program of Prof. Robin McCarley of Louisiana State University. Prof. McCarley and his students plan to investigate how to prepare stimuli responsive liposomes with the capability to deliver molecules that are internalized in the liposomes as a result of liposome destabilization. They will investigate the mechanism and kinetics associated with liposome opening by chemical reducing agents and enzymes. The project could have significant impact on various industries that focus on environmental remediation, chemical analysis and drug delivery. The project will provide excellent training opportunities to graduate and undergraduate students in a highly multidisciplinary research area. It will also support the participation of Prof. McCarley and his students in the Louisiana Board of Regents "Speaking of Science" program for K-12 students and in the LSU's ChemDemo K-12 outreach program, which has already impacted 60,000 Louisiana students.

NSF化学部的分析和表面化学项目将支持路易斯安那州立大学的Robin McCarley教授的研究项目。McCarley教授和他的学生计划研究如何制备刺激响应脂质体，该脂质体具有递送由于脂质体不稳定而内化在脂质体中的分子的能力。他们将研究与化学还原剂和酶打开脂质体相关的机制和动力学。该项目可能对专注于环境修复、化学分析和药物输送的各种行业产生重大影响。该项目将为研究生和本科生在一个高度多学科的研究领域提供良好的培训机会。它还将支持McCarley教授和他的学生参加路易斯安那州董事会为K-12学生举办的“科学演讲”计划，以及路易斯安那州立大学的ChemDemo K-12外展计划，该计划已经影响了60，000名路易斯安那州学生。