Nonlinear Optical Analysis of Molecular Composition and Dynamics within Heterogeneous Assemblies

异质组装体中分子组成和动力学的非线性光学分析

基本信息

  • 批准号:
    2305178
  • 负责人:
  • 金额:
    $ 49.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-01 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

With support from the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Professor Garth Simpson of Purdue University is developing a new imaging tool to map the chemical composition of and dynamics in heterogeneous assemblies. Understanding chemical complexity with high sensitivity and sub-micrometer spatial resolution is important for understanding the stability and bioavailability of chemical components in therapeutic materials while the presence of trace species can influence crystallization and phase transformations in two dimensional materials. Professor Simpson and his group will develop a new imaging tool based on infrared spectroscopy and molecular chirality to map the composition and translational dynamics within structurally heterogeneous assemblies. Their discoveries could lead to new approaches for extracting chemical information from images including how active molecular components are distributed in pharmaceuticals. Professor Simpson will also lead a short course on nonlinear optics and engage students in research activities.The measurement capabilities of photothermal infrared imaging will be enhanced in the fingerprinting region of the spectrum through integration of chiral spectroscopic contrast and the creation of photobleached gratings in samples. This approach is expected to resolve inhomogeneities of diffusion in traditional infrared imaging by improving both temporal and spatial resolution. By using chiral-specific spectroscopies, molecular orientation and order within microstructured assemblies will be interpreted and predicted using a mathematical framework. Chiral-specific effects predicted in the mid-infrared transmission measurements of ordered systems will then be extended to microcrystals and tissues. Finally, a spatial Fourier transform approach for fluorescence recovery after photobleaching will be used for construction of spatially-resolved maps of molecular diffusivity within heterogeneous assemblies. These local-viscosity maps have the potential to provide key details about how composition and molecular transport govern the behavior of biologically-active materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系化学测量和成像(CMI)计划的支持下,普渡大学的加思·辛普森教授正在开发一种新的成像工具,以绘制异质组件的化学组成和动力学。了解具有高灵敏度和亚微米空间分辨率的化学复杂性对于了解治疗材料中化学组分的稳定性和生物利用度是重要的,而痕量物质的存在会影响二维材料中的结晶和相变。Simpson教授和他的团队将开发一种基于红外光谱和分子手性的新成像工具,以绘制结构异质组件内的组成和平移动力学。他们的发现可能会导致从图像中提取化学信息的新方法,包括活性分子成分如何在药物中分布。Simpson教授亦会主持一个有关非线性光学的短期课程,并鼓励学生参与研究活动。透过整合手性光谱对比度及在样品中制作光漂白光栅,光热红外成像的测量能力将在光谱指纹区得到提升。该方法有望通过提高时间和空间分辨率来解决传统红外成像中的扩散不均匀性。通过使用手性特定的光谱,分子取向和微结构组件内的顺序将被解释和预测使用的数学框架。在有序系统的中红外透射测量中预测的手性特定效应将扩展到微晶和组织。最后,一个空间傅立叶变换的荧光恢复方法后,光漂白将被用于构建异构组件内的分子扩散率的空间分辨地图。这些局部粘度图有可能提供有关成分和分子传输如何控制生物活性材料行为的关键细节。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Theoretical basis for interpreting heterodyne chirality-selective sum frequency generation spectra of water
  • DOI:
    10.1063/5.0181718
  • 发表时间:
    2024-02-07
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Konstantinovsky,Daniel;Santiago,Ty;Yan,Elsa C. Y.
  • 通讯作者:
    Yan,Elsa C. Y.
Fast Diffusion Characterization by Multiphoton Excited Fluorescence Recovery while Photobleaching
  • DOI:
    10.1021/acs.analchem.3c02638
  • 发表时间:
    2023-09-12
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Li,Minghe;Razumtcev,Aleksandr;Simpson,Garth J.
  • 通讯作者:
    Simpson,Garth J.
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Garth Simpson其他文献

New Avenues for Structure Determination of Membrane Proteins
  • DOI:
    10.1016/j.bpj.2011.11.029
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Petra Fromme;Mark Hunter;Christopher Kupitz;Richard Kirian;Raimund Fromme;Anton Barty;Ingo Grotjohann;Garth Simpson;Mathias Frank;Katherina Dorner;Thomas White;Andrew Aquilla;Schlichting Ilme;Henry Chapman;John H.C. Spence
  • 通讯作者:
    John H.C. Spence
SONICC: A Novel Nonlinear Optical Detection Technique for 2D Celluar Crystallography
  • DOI:
    10.1016/j.bpj.2009.12.2074
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Fei Guo;Ellen Gualtieri;Garth Simpson;Wen Jiang
  • 通讯作者:
    Wen Jiang

Garth Simpson的其他文献

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{{ truncateString('Garth Simpson', 18)}}的其他基金

MRI: Track 1 Development of a Dual-Comb Fluorescence-Detected Photothermal Mid-Infrared (DC-FPTIR) Microscope
MRI:轨道 1 双梳荧光检测光热中红外 (DC-FPTIR) 显微镜的开发
  • 批准号:
    2320751
  • 财政年份:
    2023
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
D3SC: Nonlinear Optical Analysis of Proteins in Glasses
D3SC:玻璃中蛋白质的非线性光学分析
  • 批准号:
    2004046
  • 财政年份:
    2020
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
Phase I IUCRC at Purdue University: Center for Bioanalytic Metrology (CBM)
普渡大学 IUCCRC 第一阶段:生物分析计量中心 (CBM)
  • 批准号:
    1916691
  • 财政年份:
    2019
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Continuing Grant
Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), Purdue University
规划资助:普渡大学工业大学生物分析计量学合作研究中心(IUCRC)(CBM)
  • 批准号:
    1747786
  • 财政年份:
    2018
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
GOALI: CDS&E: Sensitively Quantifying Trace Crystallinity and Crystal Form within Pharmaceutical Formulations
目标:CDS
  • 批准号:
    1710475
  • 财政年份:
    2017
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
GOALI: Informing Amorphous Formulations Design through Quantitative Nonlinear Optical Analysis
目标:通过定量非线性光学分析为非晶配方设计提供信息
  • 批准号:
    1412888
  • 财政年份:
    2014
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
Development of a Dielectrophoretic Force Scanning Probe Microscope for Non-Contact Biological Imaging
开发用于非接触式生物成像的介电泳力扫描探针显微镜
  • 批准号:
    0923637
  • 财政年份:
    2009
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
MRI:ID - Development of an Imaging Nonlinear Optical Ellipsometer
MRI:ID - 成像非线性光学椭偏仪的开发
  • 批准号:
    0722558
  • 财政年份:
    2007
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Standard Grant
Polarization Dependent Nonlinear Optical Properties of Biomolecules
生物分子的偏振相关非线性光学性质
  • 批准号:
    0640549
  • 财政年份:
    2007
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Continuing Grant
Second Harmonic Ellipsometry and Spectroscopy of Biological Interfaces
生物界面的二次谐波椭圆测量和光谱学
  • 批准号:
    0316177
  • 财政年份:
    2003
  • 资助金额:
    $ 49.5万
  • 项目类别:
    Continuing Grant

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Quantitative analysis of polarization and charge behavior at the interface of organic devices by nonlinear optical spectroscopy.
通过非线性光谱定量分析有机器件界面的偏振和电荷行为。
  • 批准号:
    22H02048
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    2022
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D3SC: Nonlinear Optical Analysis of Proteins in Glasses
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三维非线性FDTD并行计算非线性光波导现象综合分析方法
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