Molecular assemblies in solution and on surfaces.

溶液中和表面上的分子组装体。

• 批准号: RGPIN-2022-03129
• 负责人: Kraatz, HeinzBernhard
• 金额: $ 4.52万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762171
• 关键词: Molecular; assemblies; solution; surfaces.

The research program in the Kraatz group is active at the interface of biological chemistry and electrochemistry, pursuing solution and surface studies in tandem. Research focuses on developing the chemistry of peptide bioconjugates, understanding their properties, including their interactions and aggregation forming soft gels, metal binding sites, and how these materials can be exploited for bioanalytical or materials' applications, including CO2 capture and reduction. Based on our interest to unravel fundamental issues related to the design and use of stable peptide foldamers, their aggregation into gel materials, and the use of electrochemical methods to probe the properties and reactivities of these materials, this research program focuses on two broad areas - gel materials and CO2 electroreduction. In both cases, we are exploiting the assembly of molecules to gain additional functions. Specifically this program will focus on: a) the preparation, characterization, and study of innovative stimuli responsive peptide conjugates and an investigation into the sequence-structure-function control through modulation of the hydrophilic-hydrophobic balance within the conjugate, a study of gel kinetics versus thermodynamics, and the study of new hybrid gel materials. b) the study of modified surfaces and a detailed study of the environmental effects for carbon dioxide capture and reduction. This research program will result in a more comprehensive understanding of soft gel materials and lead to a more systematic approach to tailor hydrogel materials to a given application, ranging from the removal of organic pollutants from water to influencing cell growth to drug delivery and tissue scaffolding. Research on CO2¬ electroreduction with a focus on combining direct atmospheric capture and reduction is expected to innovative solutions to the existing CO2 problem. The proposed research program creates unique and stimulating cross- disciplinary training opportunities for HQP from diverse backgrounds to work in an area of research that involves electrochemistry, biological chemistry, material chemistry as well as surface science and train the next generation of HQP for Canada's knowledge economy.

Kraatz小组的研究项目活跃于生物化学和电化学的界面，同时进行溶液和表面研究。研究重点是开发肽生物偶联物的化学，了解它们的性质，包括它们的相互作用和聚集形成软凝胶，金属结合位点，以及如何利用这些材料进行生物分析或材料的应用，包括二氧化碳捕获和减少。基于我们对揭示与稳定肽折叠物的设计和使用相关的基本问题的兴趣，它们聚集成凝胶材料，并使用电化学方法来探测这些材料的性质和反应性，本研究计划侧重于两个广泛的领域-凝胶材料和二氧化碳电还原。在这两种情况下，我们都在利用分子的组装来获得额外的功能。具体来说，该项目将侧重于：a)创新刺激响应肽偶联物的制备、表征和研究，以及通过调节偶联物内亲疏水平衡来研究序列-结构-功能控制，凝胶动力学与热力学的研究，以及新型杂交凝胶材料的研究。B)改性表面的研究和对二氧化碳捕获和减少的环境影响的详细研究。该研究项目将使人们对软凝胶材料有更全面的了解，并产生更系统的方法来定制水凝胶材料，以适应特定的应用，从去除水中的有机污染物到影响细胞生长，再到药物输送和组织支架。二氧化碳电还原研究的重点是将直接大气捕获和还原相结合，有望为现有的二氧化碳问题提供创新的解决方案。拟议的研究计划为来自不同背景的HQP创造了独特和刺激的跨学科培训机会，这些培训涉及电化学，生物化学，材料化学以及表面科学的研究领域，并为加拿大的知识经济培养下一代HQP。