Redox Neutral Reaction Cascades: Bond Forming Hydride Shift Processes

氧化还原中性反应级联：成键氢化物移位过程

• 批准号: 0911192
• 负责人: Daniel Seidel
• 金额: $ 50万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911192&HistoricalAwards=false
• 关键词: Redox; Neutral; Reaction; Cascades; Bond

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project explores reaction cascades that lead to facile C-H bond functionalization. The focus is on studying reaction cascades that are initiated by intra- or intermolecular hydride shift events that result in the formation of an electrophile/nucleophile pair. Subsequent combination of electrophile and nucleophile leads to the rapid increase of molecular complexity without the generation of byproducts. The use of catalytic approaches is an integral part of these investigations as a means of lowering activation barriers and to allow for the discovery of yet unknown rearrangements of broad applicability. An important goal is the development of catalytic enantioselective variants of hydride shift reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Daniel Seidel of the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey. Professor Seidel's research efforts revolve around the development of facile methods for organic synthesis with an emphasis on asymmetric catalysis. Such chemistry will contribute to environmentally benign methods for chemical synthesis. The successful development of the methodology will provide rapid access to valuable compounds of relevance to the pharmaceutical and agricultural industries. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。 该项目探索了导致C-H键官能化的反应级联。 重点是研究由分子内或分子间氢化物移位事件引发的反应级联，导致形成亲电体/亲核体对。 随后亲电试剂和亲核试剂的结合导致分子复杂性的快速增加而不产生副产物。 催化方法的使用是这些研究的一个组成部分，作为降低活化障碍的一种手段，并允许发现具有广泛适用性的未知重排。 一个重要的目标是开发氢化物转移反应的催化对映选择性变体。有了这个奖项，有机和大分子化学计划支持新泽西州立大学罗格斯大学化学和化学生物学系的丹尼尔·塞德尔教授的研究。 塞德尔教授的研究工作围绕着发展简便的有机合成方法，重点是不对称催化。 这种化学将有助于环境友好的化学合成方法。 该方法的成功开发将提供快速获得与制药和农业工业相关的有价值化合物的机会。 此外，该项目为培养下一代化学科学研究人员提供了理想的培训基地。