SusChEM: New Concepts for Multifunctional Asymmetric Catalysis

在这个由化学系化学合成项目资助的项目中，新玩法罗格斯大学化学系的丹尼尔塞德尔教授将试图通过探索概念上新的和欠发达的底物活化方法来推进不对称催化领域。 一个主要的目标是开发通过手性阴离子和两性离子中间体的干预产生对映体富集产物的反应。 催化量的手性阴离子受体将与简单的亲核催化剂、布朗斯台德酸和其他助催化剂和促进剂组合使用，以促进前所未有的对映选择性过程。这些策略将用于解决具有挑战性的问题，如动力学决议和胺和二胺的去对称化。 以最具成本效益的方式制备复杂手性分子的能力直接取决于可持续合成方法的可用性。 新的合成方法，将出现从这项工作将提供增强获得生物意义，手性含氮化合物，如胺，二胺，天然和非天然氨基酸，四氢喹啉生物碱，咔啉和其他含吲哚的物质，这应该反过来，有助于推进化学工业。 此外，该项目为培养下一代化学科学研究人员提供了理想的培训基地。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Daniel Seidel of the Department of Chemistry at Rutgers University, New Brunswick, will attempt to advance the field of asymmetric catalysis through exploration of conceptually new and underdeveloped methods of substrate activation. A major goal is the development of reactions that produce enantiomerically enriched products through intervention of chiral anionic and zwitterionic intermediates. Catalytic amounts of chiral anion receptors will be used in combination with simple nucleophilic catalysts, Bronsted acids and other co-catalysts and promoters to facilitate unprecedented enantioselective processes. These strategies will be used to address challenging problems such as the kinetic resolution and desymmetrization of amines and diamines. The ability to prepare complex chiral molecules in the most cost-effective way possible is directly dependent on the availability of sustainable synthetic methodologies. The new synthetic methods that will emerge from this work will provide enhanced access to biologically significant, chiral nitrogen containing compounds such as amines, diamines, natural and unnatural amino acids, tetrahydroquinoline alkaloids, carbolines and other indole containing substances, which should, in turn, help advance the chemical industry. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences.