New Concepts for Multifunctional Asymmetric Catalysis

多功能不对称催化新概念

• 批准号: 1806747
• 负责人: Daniel Seidel
• 金额: $ 35.98万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1806747&HistoricalAwards=false
• 关键词: New; Concepts; Multifunctional; Asymmetric; Catalysis

With this award, the Chemical Catalysis Program of the Chemistry Division supports the research of Professor Daniel Seidel. Professor Seidel is a member of the Department of Chemistry and Chemical Biology at Rutgers, the State University of New Jersey. This project aims to advance the field of asymmetric catalysis on a fundamental level through exploration of conceptually new and underdeveloped methods of substrate activation. Asymmetric catalysis is the development of small molecules that can achieve high selectivity in chemical reactions - producing a specific product in high prurity. Chiral molecules have a right-handed and left-handed version. These two mirror image molecules are described as enantiomers. A major goal of this resesarch is the development of reactions that produce enantiomerically enriched products through intervention of chiral ion pairs. Novel Brønsted acids and hydrogen bond donor catalysts are used to facilitate unprecedented enantioselective processes and address challenging problems. Multifunctional catalysts are being used as a means to achieve enzyme-like catalysis under mild reaction conditions. The research provides an excellent training ground for undergraduate and graduate students and preparing them for future careers in industry or academia. There is a strong commitment to engage a diverse group of students carrying out this research. The ability to prepare complex chiral molecules in the most cost-effective way possible is directly dependent on the availability of sustainable synthetic methodologies. The new synthetic methods that are emerging from this work provide enhanced access to biologically significant, chiral nitrogen containing compounds such as amines, amides, lactams, amino acids and indole containing substances that, in turn, help advance the chemical industry. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences. Students working on this project gain expertise in modern synthetic methods and laboratory techniques while being exposed to an intellectually stimulating and challenging environment that will prepare them for future careers.

有了这个奖项，化学部的化学催化计划支持教授丹尼尔赛德尔的研究。塞德尔教授是新泽西州立大学罗格斯大学化学和化学生物学系的成员。 该项目旨在通过探索概念上新的和欠发达的底物活化方法，在基础水平上推进不对称催化领域。不对称催化是小分子的发展，可以在化学反应中实现高选择性-生产高纯度的特定产品。手性分子有右旋和左旋两种形式。 这两种镜像分子被描述为对映体。本研究的一个主要目标是发展通过手性离子对的干预产生对映体富集产物的反应。 新型布朗斯特酸和氢键供体催化剂用于促进前所未有的对映选择性过程和解决具有挑战性的问题。多功能催化剂被用作在温和的反应条件下实现类酶催化的手段。 该研究为本科生和研究生提供了良好的培训场所，并为他们未来在工业或学术界的职业生涯做好准备。有一个强有力的承诺，从事这项研究的学生的多样化群体。以最具成本效益的方式制备复杂手性分子的能力直接取决于可持续合成方法的可用性。 从这项工作中出现的新合成方法提供了增强的生物学意义，手性含氮化合物，如胺，酰胺，内酰胺，氨基酸和含吲哚的物质，这反过来又有助于推进化学工业。 此外，该项目为培养下一代化学科学研究人员提供了理想的培训基地。从事该项目的学生获得现代合成方法和实验室技术的专业知识，同时接触到智力刺激和具有挑战性的环境，为他们未来的职业生涯做好准备。