New Concepts for Multifunctional Asymmetric Catalysis

多功能不对称催化新概念

基本信息

批准号：
1856613
负责人：
Daniel Seidel
金额：
$ 48.5万
依托单位：
University of Florida
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1856613&HistoricalAwards=false
关键词：
New Concepts Multifunctional Asymmetric Catalysis

项目摘要

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry supports the research of Professor Daniel Seidel of the Department of Chemistry at the University of Florida. The ability to prepare complex molecules in the most cost-effective way possible is directly dependent on the availability of sustainable synthetic methodologies. The new synthetic methods that emerge from this work may provide novel ways to make biologically important compounds such as polycyclic ethers, amines, and indole containing substances, which should, in turn, help advance the chemical industry, which itself is linked to the US economy. The research provides training for graduate and undergraduate student, preparing them for future careers in industry and academia. Underrepresented minority students are actively recruited to participate. Students working on this project gain expertise in modern synthetic methods and laboratory techniques while being exposed to an intellectually stimulating and challenging environment.This project aims to advance the field of asymmetric catalysis on a fundamental level through exploration of conceptually new and underdeveloped methods of substrate activation. A major goal is the development of reactions that produce enantiomerically enriched products through intervention of chiral ion pairs. Novel Bronsted acids and hydrogen bond donor catalysts are explored to facilitate enantioselective processes and address challenging synthetic problems. A focus is on reactions that proceed via the intermediacy of highly reactive oxocarbenium ions and related species. Multifunctional catalysts are being developed with the goal of achieving enzyme-like catalysis under mild reaction conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过此奖项，NSF化学部的化学合成计划支持佛罗里达大学化学系教授的研究。以最具成本效益的方式制备复杂分子的能力直接取决于可持续合成方法的可用性。从这项工作中出现的新合成方法可能会提供新颖的方法来使生物学上重要的化合物，例如多环芳烃，胺和含有物质的吲哚，这反过来又应帮助推进化学工业，而化学工业本身与美国经济有关。该研究为研究生和本科生提供了培训，为他们的行业和学术界的未来职业做准备。代表性不足的少数民族学生被积极招募参加。从事该项目的学生在现代合成方法和实验室技术方面获得了专业知识，同时受到智力刺激和具有挑战性的环境的影响。本项目旨在通过探索概念上新的和不发达的底物激活方法来推进基本水平的不对称催化领域。一个主要目标是开发通过手性离子对的干预产生对映体富集产物的反应。探索了新型的布隆酸和氢键供体催化剂，以促进对映选择过程并解决挑战性的合成问题。重点是通过高度反应性氧化离子和相关物种的中间人进行反应。正在开发多功能催化剂，目的是在轻微的反应条件下实现类似酶的催化。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估评估标准来通过评估来支持的。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

N-Fluorenyltryptamines as a Useful Platform for Catalytic Enantioselective Pictet–Spengler Reactions

N-芴基色胺作为催化对映选择性 Pictet-Spengler 反应的有用平台

DOI：
10.1055/a-1970-4452
发表时间：
2023
期刊：
Synthesis
影响因子：
0
作者：
Adili, Alafate;Sole, Aniket V.;Das, Bishwaprava;Matter, Megan E.;Seidel, Daniel
通讯作者：
Seidel, Daniel

Catalytic Enantioselective Approaches to the oxa-Pictet–Spengler Cyclization and Other 3,6-Dihydropyran-Forming Reactions

氧杂皮克泰·斯宾格勒环化和其他 3,6-二氢吡喃形成反应的催化对映选择性方法

DOI：
10.1055/s-0039-1690686
发表时间：
2019
期刊：
SynOpen
影响因子：
2.5
作者：
Zhu, Zhengbo;Adili, Alafate;Zhao, Chenfei;Seidel, Daniel
通讯作者：
Seidel, Daniel

A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters.

DOI：
10.1021/jacs.9b12457
发表时间：
2020-03-25
期刊：
Journal of the American Chemical Society
影响因子：
15
作者：
Lin Y;Hirschi WJ;Kunadia A;Paul A;Ghiviriga I;Abboud KA;Karugu RW;Vetticatt MJ;Hirschi JS;Seidel D
通讯作者：
Seidel D

Highly Acidic Conjugate‐Base‐Stabilized Carboxylic Acids Catalyze Enantioselective oxa‐Pictet–Spengler Reactions with Ketals

高酸性缀合物 - 碱 - 稳定的羧酸催化对映选择性氧杂 - Pictet - 与缩酮的 Spengler 反应

DOI：
10.1002/ange.201912677
发表时间：
2019
期刊：
Angewandte Chemie
影响因子：
0
作者：
Zhu, Zhengbo;Odagi, Minami;Zhao, Chenfei;Abboud, Khalil A.;Kirm, Helmi Ulrika;Saame, Jaan;Lõkov, Märt;Leito, Ivo;Seidel, Daniel
通讯作者：
Seidel, Daniel