New Concepts for Multifunctional Asymmetric Catalysis

多功能不对称催化新概念

• 批准号: 1565599
• 负责人: Daniel Seidel
• 金额: $ 45万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565599&HistoricalAwards=false
• 关键词: New; Concepts; Multifunctional; Asymmetric; Catalysis

With this award, the Chemical Catalysis Program of the Chemistry Division supports the research of Professor Daniel Seidel. Professor Seidel is a member of the Department of Chemistry and Chemical Biology at Rutgers, the State University of New Jersey. This project aims to advance the field of asymmetric catalysis on a fundamental level through exploration of conceptually new and underdeveloped methods of substrate activation. Asymmetric catalysis is the development of small molecules that can achieve high selectivity in chemical reactions - producing a specific product in high prurity. Chiral molecules have a right-handed and left-handed version. These two mirror image molecules are described as enantiomers. A major goal of this resesarch is the development of reactions that produce enantiomerically enriched products through intervention of chiral ion pairs. Novel Brønsted acids and hydrogen bond donor catalysts are used to facilitate unprecedented enantioselective processes and address challenging problems. Multifunctional catalysts are being used as a means to achieve enzyme-like catalysis under mild reaction conditions. The research provides an excellent training ground for undergraduate and graduate students and preparing them for future careers in industry or academia. There is a strong commitment to engage a diverse group of students carrying out this research. The ability to prepare complex chiral molecules in the most cost-effective way possible is directly dependent on the availability of sustainable synthetic methodologies. The new synthetic methods that are emerging from this work provide enhanced access to biologically significant, chiral nitrogen containing compounds such as amines, amides, lactams, amino acids and indole containing substances that, in turn, help advance the chemical industry. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences. Students working on this project gain expertise in modern synthetic methods and laboratory techniques while being exposed to an intellectually stimulating and challenging environment that will prepare them for future careers.

通过此奖项，化学部的化学催化计划支持丹尼尔·塞德尔教授的研究。 Seidel教授是新泽西州立大学罗格斯化学与化学生物学系的成员。该项目旨在通过探索概念上新的和欠发达的底物激活方法来推进基本层面上不对称催化的领域。不对称催化是小分子的发展，可以在化学反应中获得高选择性 - 在高实践中产生特定产物。手性分子具有右撇子和左手的版本。这两个镜像分子被描述为对映异构体。该ressesarch的主要目标是发展反应，通过干预手性离子对产生对映体富集的产品。新型的BrønstedAcid和氢键供体催化剂用于促进前所未有的对映选择过程并解决挑战问题。在轻度反应条件下，多功能催化剂被用作实现酶样催化的手段。这项研究为本科生和研究生提供了良好的培训理由，并为他们的行业或学术界的未来职业做准备。有一个坚定的承诺，致力于吸引一群学生进行这项研究。以最具成本效益的方式制备复杂的手性分子的能力直接取决于可持续合成方法的可用性。这项工作中出现的新合成方法可增强对具有生物学意义的手性氮的获取，其中含有胺，酰胺，酰胺，乳糖，氨基酸，氨基酸和含有含有物质的化合物，从而有助于推进化学工业。此外，该项目提供了理想的训练场，以准备化学科学领域的下一代研究人员。从事该项目的学生在现代合成方法和实验室技术方面获得了专业知识，同时接触了智力刺激和挑战性的环境，这将为未来的职业做好准备。