New Concepts for Multifunctional Asymmetric Catalysis

通过这个奖项，化学部的化学催化项目支持了Daniel Seidel教授的研究。塞德尔教授是新泽西州立大学罗格斯分校化学和化学生物学系的成员。该项目旨在通过探索概念新颖和不发达的底物活化方法，在基础水平上推进不对称催化领域。不对称催化是在化学反应中实现高选择性的小分子的发展-产生高纯度的特定产物。手性分子有左手型和右手型。这两个镜像分子被称为对映体。本研究的一个主要目标是通过手性离子对的干预来开发产生对映体富集产物的反应。新型Brønsted酸和氢键供体催化剂用于促进前所未有的对映选择性过程，并解决具有挑战性的问题。多功能催化剂是在温和反应条件下实现类酶催化的一种手段。这项研究为本科生和研究生提供了一个很好的训练基地，为他们未来在工业界或学术界的职业生涯做准备。有一个强有力的承诺，让不同群体的学生进行这项研究。以最具成本效益的方式制备复杂手性分子的能力直接取决于可持续合成方法的可用性。从这项工作中出现的新的合成方法提供了更多的生物意义，手性含氮化合物，如胺，酰胺，内酰胺，氨基酸和含吲哚的物质，反过来，有助于推进化学工业。此外，该项目为培养下一代化学科学研究人员提供了理想的培训场所。参与该项目的学生将获得现代合成方法和实验室技术方面的专业知识，同时接触到一个智力刺激和具有挑战性的环境，为他们未来的职业生涯做好准备。

With this award, the Chemical Catalysis Program of the Chemistry Division supports the research of Professor Daniel Seidel. Professor Seidel is a member of the Department of Chemistry and Chemical Biology at Rutgers, the State University of New Jersey. This project aims to advance the field of asymmetric catalysis on a fundamental level through exploration of conceptually new and underdeveloped methods of substrate activation. Asymmetric catalysis is the development of small molecules that can achieve high selectivity in chemical reactions - producing a specific product in high prurity. Chiral molecules have a right-handed and left-handed version. These two mirror image molecules are described as enantiomers. A major goal of this resesarch is the development of reactions that produce enantiomerically enriched products through intervention of chiral ion pairs. Novel Brønsted acids and hydrogen bond donor catalysts are used to facilitate unprecedented enantioselective processes and address challenging problems. Multifunctional catalysts are being used as a means to achieve enzyme-like catalysis under mild reaction conditions. The research provides an excellent training ground for undergraduate and graduate students and preparing them for future careers in industry or academia. There is a strong commitment to engage a diverse group of students carrying out this research. The ability to prepare complex chiral molecules in the most cost-effective way possible is directly dependent on the availability of sustainable synthetic methodologies. The new synthetic methods that are emerging from this work provide enhanced access to biologically significant, chiral nitrogen containing compounds such as amines, amides, lactams, amino acids and indole containing substances that, in turn, help advance the chemical industry. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences. Students working on this project gain expertise in modern synthetic methods and laboratory techniques while being exposed to an intellectually stimulating and challenging environment that will prepare them for future careers.