SBIR Phase I: Molecular diagnostics and biological control of disease in farmed channel catfish

SBIR 第一阶段：养殖斑点叉尾鮰疾病的分子诊断和生物控制

• 批准号: 0912233
• 负责人: Thomas Schoenfeld
• 金额: $ 10万
• 依托单位: LUCIGEN CORPORATION
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0912233&HistoricalAwards=false
• 关键词: SBIR; Phase; Molecular; diagnostics; biological

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Small Business Innovation Research Phase I project is aimed at developing an effective, inexpensive, safe means of controlling infectious diseases among farmed catfish. An integrated system of detection and control is targeted at Edwardsiella ictaluri, the most costly pathogen among farmed catfish. Detection is based on rapid, simple tests for pathogen genes. Control is based on naturally occurring viruses and bacteria. Together these technologies comprise an integrated system for rapidly and inexpensively detecting and treating catfish more safely, inexpensively and specifically. This approach is generally applicable to pathogens affecting a wide range of farmed fish.As commercial wild harvest of most fish species is proving unsustainable, farmed fish are increasingly significant as a food source and an important industry, often in underdeveloped parts of US and the rest of the world. A major impediment to developing this industry is infectious disease due to unnaturally high densities of fish that cause losses of up to half of the fish worth billions of dollars worldwide. There is currently no satisfactory means of controlling these outbreaks. Alternatives including antibiotics, vaccines, chemicals or controlled feeding are either expensive, harmful to human and environmental health and/or detrimental to yields. The immediate focus of this proposal, Enteric Septicemia of Catfish due to Edwardsiella ictaluri, addresses the $20-30M in losses and promises to improve the viability of an important source of income to the rural southeastern US. Longer term, this approach will be applied to other fish species throughout the US and the world.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。这个小企业创新研究第一阶段项目旨在开发一种有效，廉价，安全的方法来控制养殖鲶鱼中的传染病。一个综合的检测和控制系统是针对爱德华氏菌，养殖鲶鱼中最昂贵的病原体。检测是基于快速，简单的病原体基因测试。控制是基于自然发生的病毒和细菌。这些技术共同构成了一个集成系统，可以更安全、更便宜、更有针对性地快速、廉价地检测和治疗鲶鱼。这种方法通常适用于影响各种养殖鱼类的病原体。由于大多数鱼类物种的商业野生捕捞被证明是不可持续的，养殖鱼类作为食物来源和重要产业越来越重要，通常在美国和世界其他地区的欠发达地区。发展这一产业的一个主要障碍是由于鱼类不自然的高密度而造成的传染病，这种疾病在全世界造成高达一半的鱼类损失，价值数十亿美元。目前还没有令人满意的方法来控制这些疾病的爆发。包括抗生素、疫苗、化学品或控制饲养在内的替代品要么价格昂贵，对人类和环境健康有害，要么不利于产量。该提案的直接重点是由爱德华氏菌引起的鲶鱼肠败血症，解决了2000万至3000万美元的损失，并有望提高美国东南部农村重要收入来源的可行性。从长远来看，这种方法将适用于美国和世界各地的其他鱼类。