SBIR Phase II: Molecular Diagnostics and Biological Control of Disease in Farmed Channel Catfish

SBIR 第二阶段：养殖斑点叉尾鮰疾病的分子诊断和生物控制

• 批准号: 1058238
• 负责人: Thomas Schoenfeld
• 金额: $ 50万
• 依托单位: LUCIGEN CORPORATION
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058238&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Molecular; Diagnostics

This Small Business Innovation Research (SBIR) Phase II project is aimed at developing an effective, inexpensive, safe means of controlling diseases in farm-raised catfish. One of the biggest problems in farm-raised catfish is disease that occurs in commercial ponds. Scientists at Auburn University discovered strains of natural bacteria that can be applied to fish feed to control the most common diseases. Lucigen is developing rapid, simple tests capable of detecting these diseases before the fish get sick. The goal is to combine these ideas to develop commercial products to rapidly diagnose and treat the most common catfish diseases. The broader impacts of this research are 1) the preservation of an important industry in economically disadvantaged regions of the rural southeastern US and 2) protection of an increasingly important food source. Since yields of most wild-caught fish are declining, farmed fish are becoming an important food source and an important industry throughout the world. Fish diseases in aquaculture ponds cause losses of up to half the fish before harvest, costing billions of dollars worldwide, and there is no satisfactory means of controlling most of these outbreaks. Antibiotics, vaccines, chemicals or controlled feeding are all prohibitively expensive, harmful to human and environmental health and/or bad for yields. The detection and control of catfish diseases, the immediate focus of this project, addresses the $20-30M in annual losses caused by disease. Longer term, similar biological control systems should be applicable to other fish species in the US and the rest of the world.

小企业创新研究（SBIR）第二阶段项目旨在开发一种有效，廉价，安全的方法来控制养殖鲶鱼的疾病。养殖鲶鱼的最大问题之一是商业池塘中发生的疾病。奥本大学的科学家们发现了一种天然细菌菌株，可以应用于鱼类饲料来控制最常见的疾病。Lucigen正在开发快速，简单的测试，能够在鱼生病之前检测到这些疾病。我们的目标是将这些想法联合收割机开发出商业产品，以快速诊断和治疗最常见的鲶鱼疾病。这项研究的更广泛的影响是：1）保护美国东南部农村经济落后地区的重要产业; 2）保护日益重要的食物来源。由于大多数野生鱼类的产量正在下降，养殖鱼类正在成为世界各地的重要食物来源和重要产业。水产养殖池塘中的鱼类疾病在收获前造成多达一半的鱼类损失，在全世界造成数十亿美元的损失，并且没有令人满意的方法来控制大多数这些疾病的爆发。抗生素、疫苗、化学品或控制喂养都是昂贵的，对人类和环境健康有害和/或不利于产量。鲶鱼疾病的检测和控制是该项目的直接重点，解决了每年因疾病造成的2000万至3000万美元的损失。从长远来看，类似的生物控制系统应该适用于美国和世界其他地区的其他鱼类。