SBIR Phase I: Development of Miniature Endoscopic Imaging Probes for In Vivo Noninvasive Optical Imaging for Early Diagnosis of Lung Cancer

SBIR 第一阶段：开发用于肺癌早期诊断的体内无创光学成像的微型内窥镜成像探针

• 批准号: 0912734
• 负责人: Lei Wu
• 金额: --
• 依托单位: WiOptix, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0912734&HistoricalAwards=false
• 关键词: SBIR; Phase; Development; Miniature; Endoscopic

This Small Business Innovative Research (SBIR) Phase I project an Optical coherence tomography (OCT) imaging MEMS-based probe of 2.8 mm diameter will be designed and manufactured. The plan is to apply MEMS design and wire bonding free packaging techniques for miniaturization of the probe. In this MEMS design the mirror will have high fill factor and bonding pads on the opposite chip side of the reflective mirror surface. The MEMS mirror and the other optical component will be packaged into the MEMS-based probe; the probe will be attached with the existing OCT system, and then will be tested for lung imaging. The proposed MEMS-based OCT system has the potential to be a low-cost tool for rapid diagnosis or screening of lung cancer at the point of care. It is also expected that the technology could be used for other OCT systems for internal organ imaging. If successful the proposed MEMS design and wire bonding-free (WBF) packaging technique can be applied virtually to all optical imaging systems including coherence, confocal, nonlinear and adaptive optical imaging. They can also be used in laser scanning displays and optical telecommunications. This effort may lead to the world?s first MEMS-based OCT applicable to rapid diagnosis or screening of lung cancer at the point of care (e.g., bedside or office). Due to its low-cost and disposable nature, it is particularly suitable for field use without the need of sterilization equipments. Although the focus of this proposal is on a MEMS based endoscopic OCT system for bronchoscopy, the key technology developed can be adapted for other compact OCT systems for internal organ imaging. The MEMS-based endoscopic OCT probe is applicable to diagnosis and image-guided surgery of various internal cancers such as prostate, colon, rectal, and gastro-intestinal cancers."This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."

该小型企业创新研究（SBIR）第一阶段项目将设计和制造直径为2.8 mm的光学相干断层扫描（OCT）成像MEMS探头。该计划是应用MEMS设计和引线键合自由封装技术的小型化的探头。在该MEMS设计中，反射镜将具有高填充因子和在反射镜表面的相对芯片侧上的接合焊盘。MEMS镜和其他光学组件将被封装到基于MEMS的探头中;探头将与现有OCT系统连接，然后将进行肺部成像测试。所提出的基于MEMS的OCT系统有可能成为一种低成本的工具，用于在护理点快速诊断或筛查肺癌。还预计该技术可用于其他OCT系统，用于内部器官成像。 如果成功的话，所提出的MEMS设计和无引线键合（WBF）封装技术几乎可以应用于所有的光学成像系统，包括相干，共焦，非线性和自适应光学成像。它们也可用于激光扫描显示器和光学通信。这种努力可能会导致世界？首款基于MEMS的OCT可用于在护理点快速诊断或筛查肺癌（例如，床边或办公室）。由于其低成本和一次性使用的性质，它特别适合于现场使用，而无需灭菌设备。尽管该提案的重点是基于MEMS的用于支气管镜检查的内窥镜OCT系统，但所开发的关键技术可适用于用于内部器官成像的其他紧凑型OCT系统。基于MEMS的内窥镜OCT探头适用于前列腺癌、结肠癌、直肠癌和胃肠道癌等各种内部癌症的诊断和图像引导手术。“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。"