Selective Aqueous-phase Adhesion by Molecularly Engineered Materials

分子工程材料的选择性水相粘附

• 批准号: 0927778
• 负责人: Dennis Bong
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0927778&HistoricalAwards=false
• 关键词: Selective; Aqueous; phase; Adhesion; Molecularly

The research objective of this award is to determine the mechanism of hydrogen-bonding directed molecular recognition in water and the installation of such motifs onto known polymeric scaffolds. This study will provide a quantitative basis for consideration of hydrogen bonds in aqueous environment in the context of a synthetic or bio-derived scaffold. This fundamental component of the award lays the groundwork for incorporation of selective hydrogen bonding groups onto different polymeric backbones. It is anticipated that the use of selective recognition groups on natural and synthetic polymers will lead to enhanced function. Selective heteropolymeric interaction guided by hydrogen-bonding has great potential utility, especially in the context of surface coatings. Overall, this work traces an arc from study of molecular properties to the production of chemically-responsive, biocompatible and biodegradable materials.If successful, selective surface adhesion would be possible in water, with no oxidative or photocuring required, making it widely applicable as a ?molecular Velcro?, which would allow only designated coated surfaces to adhere. This would be useful in a number of industrial ad biomedical applications, such as in marine environment coatings or biocompatible surface adhesives as suture alternatives, and hydrogels for drug delivery and tissue engineering. This research bridges synthetic chemistry, materials science, engineering and biomedical research and will facilitate new cross-disciplinary educational experiences for graduate and undergraduate students. Students will also be exposed to the practical aspects of developing a new materials application. The simple hands-on experimental approach to molecular recognition concepts is amenable to incorporation into instructional labs. It is anticipated that development of a general methodology to enhance the synthetic and biopolymer function will have a transformative impact on both the agricultural and coatings industry with significant economic and environmental benefit.

该奖项的研究目标是确定氢键定向分子识别在水中的机制，并将此类基序安装到已知的聚合物支架上。 这项研究将提供一个定量的基础上考虑在水环境中的氢键的背景下，合成或生物衍生的支架。 该奖项的基本组成部分为将选择性氢键基团结合到不同的聚合物主链上奠定了基础。 预计在天然和合成聚合物上使用选择性识别基团将导致增强的功能。 由氢键引导的选择性杂聚相互作用具有巨大的潜在用途，特别是在表面涂层的背景下。 总体而言，这项工作的痕迹弧从分子特性的研究，以生产化学响应，生物相容性和可生物降解的材料。如果成功的话，选择性的表面粘附将可能在水中，没有氧化或光固化所需的，使其广泛适用于作为一个？分子维可牢？这将仅允许指定的涂覆表面粘附。 这将在许多工业和生物医学应用中是有用的，例如在海洋环境涂层或作为缝合替代物的生物相容性表面粘合剂，以及用于药物递送和组织工程的水凝胶中。 这项研究桥接了合成化学，材料科学，工程和生物医学研究，并将为研究生和本科生提供新的跨学科教育经验。 学生还将接触到开发新材料应用的实践方面。分子识别概念的简单动手实验方法适合纳入教学实验室。 预计开发一种增强合成和生物聚合物功能的通用方法将对农业和涂料行业产生变革性影响，并带来显著的经济和环境效益。