Bioinspired Glycomaterials from Lipid and Polymer Tehalose Conjugates

来自脂质和聚合物泰藻糖缀合物的仿生糖材料

• 批准号: 1410232
• 负责人: Dennis Bong
• 金额: $ 45万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1410232&HistoricalAwards=false
• 关键词: Bioinspired; Glycomaterials; Lipid; Polymer; Tehalose

Nontechnical: This award by the Biomaterials Program in the Division of Materials Research to Ohio State University is focused on a fundamental surface science question, yet has the potential to produce new bioinspired materials for therapeutic delivery, cryogenic preservation of tissues and organs and stabilization of sensitive bioactive molecules. The discovery of an efficient tissue and organ cryoprotectant would serve a major medical need, allowing longer term storage of organs for transplant. Furthermore, while considerable biomedical research to develop new therapeutics, many of these reagents (biologics, liposomes) must be administered intravenously and can't be stored as a powder or at room temperature. This greatly limits their application in developing countries where modern cold storage facilities are not widely available or reliable. The production of a trehalose biomaterial that could stabilize sensitive pharmaceuticals to a wide range of environmental conditions (heat, low hydration, freeze-dried state) would be of tremendous benefit to communities in developing countries. This expansion of the reach of modern therapeutics could have a deep and lasting impact on many societies outside the first world. Technical: A long term goal of the proposed research program is the elucidation of assembly and biophysical properties of trehalose-derived amphiphiles. The objective of this application is to ascertain the structural determinants of trehalose anhydrobiotic protection. Assemblies will be synthesized and characterized that use trehalose as the hydrophilic component of lipid and polymer amphiphilic systems. The central hypothesis of this proposal is that synthetic assemblies that surface display trehalose will exhibit remarkable stability under anhydrobiotic conditions. The rationale for this hypothesis is based on the finding that synthetic trehalose-functionalized lipids and lipid-polymers can protect lipid bilayers against air-drying and freeze-drying in the context of supported lipid bilayers (SLBs) and vesicular bilayers. These new trehalose materials are predicted to exhibit function beyond simple amphiphilic assembly, conferring the anhydrobiotic and cryogenic protective properties of trehalose to the synthetic material. In the course of this project, students at the undergraduate and graduate levels will be trained in chemical synthesis and materials characterization, and preparing them to enter the workforce in chemical and engineering sciences with experience working with novel materials.

非技术性：该奖项由俄亥俄州州立大学材料研究部生物材料项目授予，重点关注一个基本的表面科学问题，但有可能产生新的生物启发材料，用于治疗输送、组织和器官的低温保存以及敏感生物活性分子的稳定。有效的组织和器官冷冻保护剂的发现将满足主要的医疗需求，允许更长期地储存器官用于移植。此外，虽然大量的生物医学研究开发新的治疗方法，许多这些试剂（生物制剂，脂质体）必须静脉注射，不能作为粉末或在室温下储存。这极大地限制了它们在发展中国家的应用，因为这些国家的现代冷藏设施并不普遍或不可靠。海藻糖生物材料的生产可以使敏感药物在各种环境条件下（高温、低水合、冻干状态）保持稳定，这将给发展中国家的社区带来巨大的好处。现代治疗方法的扩展可能会对第一世界以外的许多社会产生深刻而持久的影响。技术支持：一个长期的目标，拟议的研究计划是阐明海藻糖衍生的两亲物的组装和生物物理性质。本申请的目的是确定海藻糖脱水生物保护的结构决定因素。将合成并表征使用海藻糖作为脂质和聚合物两亲性系统的亲水组分的组装体。该建议的中心假设是，表面展示海藻糖的合成组件将在脱水条件下表现出显着的稳定性。该假设的基本原理是基于以下发现：合成海藻糖官能化的脂质和脂质聚合物可以在支撑的脂质双层（SLB）和囊泡双层的情况下保护脂质双层免受空气干燥和冷冻干燥。 这些新的海藻糖材料被预测表现出超越简单的两亲性组装的功能，赋予海藻糖的脱水和低温保护性能的合成材料。 在这个项目的过程中，学生在本科和研究生水平将在化学合成和材料表征的培训，并准备他们进入劳动力在化学和工程科学与新材料的工作经验。