Electrode Arrays for Neurodynamic Studies

用于神经动力学研究的电极阵列

• 批准号: 0933234
• 负责人: Massood Tabib-Azar
• 金额: $ 29.21万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0933234&HistoricalAwards=false
• 关键词: Electrode; Arrays; Neurodynamic; Studies

0652043Tabib-AzarThe main objective of this research is to design and implement an array of sensing and stimulating electrodes with integrated low-power electronics and telemetry to study dynamics of the nervous system in intact and behaving animals. A minimally intrusive implantable electrode array capable of recording and stimulating at multiple sites in the nervous system will be used. An experimental preparation in which the dynamics of the nervous system (i.e., the activity in single nerve cells) can be readily related to its overall behavior will be used. The novelty of the proposed system is that it will make it possible to record and control neural activity simultaneously through a remote computer interface. In turn, this will allow novel studies of neurodynamics, since it will be possible to examine the response of the nervous system to specific stimuli. For this reason, the electrode array system will be developed for a biological organism whose neural control and biomechanics have been very well characterized, the marine mollusk Aplysia californica. Results of this research will ultimately have broader applications in human neural prostheses.The design and fabrication of an 8x8 stimulation and sensing electrode array with different electrode geometries and coating materials to optimize recording and stimulation of many Aplysia neurons simultaneously is proposed. In parallel, design and implementation of a low-power data acquisition and telemetry electronics will take place. These devices will be tested separately and together, forming the sense/stimulate telemetry system in vitro and in vivo in isolated ganglia, semi-intact preparations and in intact and behaving animals.

0652043 Tabib-Azar本研究的主要目的是设计和实现一系列传感和刺激电极，集成低功耗电子器件和遥测技术，以研究完整和行为动物神经系统的动力学。将使用能够在神经系统的多个部位进行记录和刺激的微创植入式电极阵列。 一种实验准备，其中神经系统的动力学（即，单个神经细胞中的活动）可以容易地与其整体行为相关。该系统的新奇在于，它将使通过远程计算机接口同时记录和控制神经活动成为可能。反过来，这将允许神经动力学的新研究，因为它将有可能检查神经系统对特定刺激的反应。出于这个原因，电极阵列系统将被开发用于其神经控制和生物力学已经被很好地表征的生物有机体，海洋软体动物加州海蛞蝓。本研究的结果最终将在人类神经假体中有更广泛的应用。提出了一种具有不同电极几何形状和涂层材料的8 × 8刺激和传感电极阵列的设计和制造，以优化同时记录和刺激多个失智神经元。与此同时，将设计和实施低功率数据采集和遥测电子设备。这些器械将分别和一起进行测试，在离体神经节、半完整制剂和完整和行为动物中形成体外和体内感知/刺激遥测系统。