Cross-Course Collaboration in the Undergraduate Chemistry Curriculum

化学系正在实施使用气相色谱-质谱（GCMS）能够电子冲击（EI）和化学电离（CI）模式，并能够串联质谱（MSMS）。该仪器是一种重要的分析工具，用于化学，特别是在环境，制药和生化应用。该仪器被用于支持有机、无机和物理化学领域的实验，并影响了四门本科课程，包括课程间的材料交换和大二有机化学和物理化学实验室的跨课程合作。学生们正在进行化学反应中的动力学同位素效应、拜耳村民氧化中的区域选择性、使用威尔金森催化剂选择性还原柠檬烯、化学电离质谱和串联质谱，以及使用雅各布森催化剂进行对映选择性环氧化。该仪器也用于本科研究项目，包括天然产物的分离和合成和有机合成。这些项目每年涉及5-10名本科生研究生，而课程相关项目每年涉及90-120名本科生。邻近的女子学院圣玛丽森林学院（Saint Mary of the Woods college）没有自己的乐器，该校的学生也使用这种乐器。此外，附近学校的高中老师与学生一起参加了一个项目，该项目涉及对水果糖和薄荷叶进行气相色谱色谱顶空分析，作为化学“嗅探器”。知识价值。在课程中使用动手操作的GCMS向本科生介绍了这种化学分析的常用分析工具，并允许学生从学习的早期点解决科学问题。针对高中学生的外展项目说明了使用GCMS作为识别挥发性物质的工具。二年级有机实验室介绍了GCMS的实践和理论，进行了同位素标记和结构解析分析。介绍了化学电离和串联质谱法在高级有机实验室中的先进应用。有机化学和物理化学学生通过交换同位素标记和动力学同位素效应实验的材料和数据进行合作，包括学生向每个小组做报告。二年级有机实验室和无机实验室之间，以及无机实验室和高级有机实验室之间，根据课程之间传递的材料进行交换。这些相互作用促进了材料和数据的所有权以及课程之间的概念联系，包括化合物可以出于实用目的分离或合成的想法，以及回答化学问题（区域选择性/反应机制）。这种体验的预期结果是，学生们通过看到课程内容与其重要性之间的联系而更加投入。此外，学生们希望通过实践经验来做好更多的准备，获得研究生和专业学习或工业化学职业所需的技能。更广泛的影响。这一工具的使用对该部门和机构的教育和研究基础设施产生了重大影响。获得现代最先进的仪器对该部门的课程和研究培训至关重要。该系在本科生研究方面有着悠久的历史，几乎所有的毕业生都参与过某种形式的本科生研究。印第安纳州立大学是印第安纳州少数族裔学生比例第二高的大学，女学生占很大比例。

The Department of Chemistry is implementing the use of a gas chromatograph-mass (GCMS) capable of electron impact (EI) and chemical ionization (CI) modes and capable of tandem mass spectrometry (MSMS). This instrument is an important analytical tool for use in chemistry, especially in environmental, pharmaceutical, and biochemical applications. This instrument is being used to support experiments in the fields of organic, inorganic, and physical chemistry and is impacting four undergraduate courses including materials exchange between courses and a cross-course collaboration between the sophomore organic and physical chemistry laboratories. Students are carrying out kinetic isotope effects in a chemical reaction, regioselectivity in the Bayer Villager oxidation, selective reduction of limonene with Wilkinson's Catalyst, chemical ionization MS and Tandem Mass Spectrometry, and enantioselective epoxidation using Jacobsen's catalyst. The instrument also is used in undergraduate research for projects that include natural product isolation and synthesis and organic synthesis. These projects involve 5-10 undergraduate research students per year, while the course-related projects involve 90-120 undergraduate students per year. Students from a neighboring women's college, Saint Mary of the Woods College, which does not have an instrument of its own, also use the instrument. Further, high school teachers from nearby schools participate with students in a program involving GCMS headspace analysis of fruit candy and mint leaves as a chemical "sniffer." Intellectual Merit. The use of hands-on GCMS in the curriculum introduces the undergraduate students to this common analytical tool for chemical analysis and allows students to address scientific questions from an early point in their learning. The outreach programs to high school students illustrate the use of GCMS as a tool to identify volatile substances. GCMS practice and theory is introduced in Sophomore Organic laboratory for analysis of isotopic labeling and structure elucidation. Advanced applications of chemical ionization and tandem mass spectrometry are introduced in the Advanced Organic laboratory. Organic and physical chemistry students collaborate via exchange of materials and data from isotopic labeling and kinetic isotope effect experiments including presentations by students to each group. Exchanges take place between the Sophomore Organic and the Inorganic laboratories, as well as between the Inorganic and Advanced Organic laboratories, from materials that are passed between courses. These interactions promote ownership of materials and data as well as conceptual connections between the courses, including the idea that compounds can be isolated or synthesized for pragmatic purposes, as well as for answering chemical questions (regioselectivity/reaction mechanism). The expected outcome of this experience is students who are more engaged by seeing the connections between content in their courses and its importance. Also, students are expected to be more prepared by hands on experience, obtaining needed skills for graduate and professional studies or industrial chemical careers. Broader Impacts. The use of this instrument is having a significant impact on the educational and research infrastructure of the department and the institution. Access to modern state-of-the-art instrumentation is critical to curricular and research training in the department. The department has a long history of undergraduate research and nearly all of the graduates have been involved in some form of undergraduate research. Indiana State University has the second largest percentage of minority students in Indiana and serves a large proportion of female students.