Cross-Course Collaboration in the Undergraduate Chemistry Curriculum

本科化学课程中的跨课程合作

• 批准号: 0942345
• 负责人: Richard Fitch
• 金额: $ 10.73万
• 依托单位: Indiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0942345&HistoricalAwards=false
• 关键词: Cross; Course; Collaboration; Undergraduate; Chemistry

The Department of Chemistry is implementing the use of a gas chromatograph-mass (GCMS) capable of electron impact (EI) and chemical ionization (CI) modes and capable of tandem mass spectrometry (MSMS). This instrument is an important analytical tool for use in chemistry, especially in environmental, pharmaceutical, and biochemical applications. This instrument is being used to support experiments in the fields of organic, inorganic, and physical chemistry and is impacting four undergraduate courses including materials exchange between courses and a cross-course collaboration between the sophomore organic and physical chemistry laboratories. Students are carrying out kinetic isotope effects in a chemical reaction, regioselectivity in the Bayer Villager oxidation, selective reduction of limonene with Wilkinson's Catalyst, chemical ionization MS and Tandem Mass Spectrometry, and enantioselective epoxidation using Jacobsen's catalyst. The instrument also is used in undergraduate research for projects that include natural product isolation and synthesis and organic synthesis. These projects involve 5-10 undergraduate research students per year, while the course-related projects involve 90-120 undergraduate students per year. Students from a neighboring women's college, Saint Mary of the Woods College, which does not have an instrument of its own, also use the instrument. Further, high school teachers from nearby schools participate with students in a program involving GCMS headspace analysis of fruit candy and mint leaves as a chemical "sniffer." Intellectual Merit. The use of hands-on GCMS in the curriculum introduces the undergraduate students to this common analytical tool for chemical analysis and allows students to address scientific questions from an early point in their learning. The outreach programs to high school students illustrate the use of GCMS as a tool to identify volatile substances. GCMS practice and theory is introduced in Sophomore Organic laboratory for analysis of isotopic labeling and structure elucidation. Advanced applications of chemical ionization and tandem mass spectrometry are introduced in the Advanced Organic laboratory. Organic and physical chemistry students collaborate via exchange of materials and data from isotopic labeling and kinetic isotope effect experiments including presentations by students to each group. Exchanges take place between the Sophomore Organic and the Inorganic laboratories, as well as between the Inorganic and Advanced Organic laboratories, from materials that are passed between courses. These interactions promote ownership of materials and data as well as conceptual connections between the courses, including the idea that compounds can be isolated or synthesized for pragmatic purposes, as well as for answering chemical questions (regioselectivity/reaction mechanism). The expected outcome of this experience is students who are more engaged by seeing the connections between content in their courses and its importance. Also, students are expected to be more prepared by hands on experience, obtaining needed skills for graduate and professional studies or industrial chemical careers. Broader Impacts. The use of this instrument is having a significant impact on the educational and research infrastructure of the department and the institution. Access to modern state-of-the-art instrumentation is critical to curricular and research training in the department. The department has a long history of undergraduate research and nearly all of the graduates have been involved in some form of undergraduate research. Indiana State University has the second largest percentage of minority students in Indiana and serves a large proportion of female students.

化学系正在实施使用气相色谱质谱仪（GCMS），能够电子碰撞（EI）和化学电离（CI）模式，并能够串联质谱（MSMS）。该仪器是化学中使用的重要分析工具，特别是在环境，制药和生物化学应用中。该仪器用于支持有机，无机和物理化学领域的实验，并影响四门本科课程，包括课程之间的材料交换以及大二有机和物理化学实验室之间的跨课程合作。 学生们正在进行化学反应中的动力学同位素效应，拜耳村民氧化的区域选择性，用威尔金森催化剂选择性还原柠檬烯，化学电离MS和串联质谱，以及使用Jacobsen催化剂的对映选择性环氧化。 该仪器还用于本科生研究项目，包括天然产物的分离和合成以及有机合成。这些项目每年涉及5-10名本科研究生，而课程相关项目每年涉及90-120名本科生。附近一所女子学院的学生，伍兹学院的圣玛丽，没有自己的乐器，也使用这种乐器。此外，来自附近学校的高中教师与学生一起参加了一个项目，该项目涉及水果糖果和薄荷叶的GCMS顶空分析作为化学品“嗅探器”。“智力优势。 在课程中使用动手GCMS向本科生介绍了这种常见的化学分析工具，并允许学生从学习的早期开始解决科学问题。对高中生的推广计划说明了GCMS作为识别挥发性物质的工具的使用。 介绍了大二有机实验室气相色谱质谱联用技术在同位素标记和结构解析方面的实践和理论。介绍了化学电离和串联质谱在高等有机实验室的应用。有机和物理化学的学生通过交换同位素标记和动力学同位素效应实验的材料和数据进行合作，包括学生向每组进行演示。交流发生在二年级有机和无机实验室之间，以及无机和高级有机实验室之间，从课程之间传递的材料。这些互动促进了材料和数据的所有权以及课程之间的概念联系，包括化合物可以被分离或合成用于实用目的的想法，以及回答化学问题（区域选择性/反应机制）。这种体验的预期结果是学生通过看到课程内容与其重要性之间的联系而更加参与。此外，学生有望通过实践经验做好更多准备，获得研究生和专业学习或工业化学职业所需的技能。更广泛的影响。 该工具的使用对该部门和机构的教育和研究基础设施产生了重大影响。获得现代国家的最先进的仪器是至关重要的课程和研究培训部门。该系有着悠久的本科研究历史，几乎所有的毕业生都参与了某种形式的本科研究。印第安纳州州立大学的少数民族学生比例在印第安纳州排名第二，并为大部分女学生提供服务。