MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer

MRI：购买 400 MHz 核磁共振波谱仪

• 批准号: 0521075
• 负责人: Richard Fitch
• 金额: $ 28.4万
• 依托单位: Indiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521075&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Nuclear

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Indiana State University will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer. Faculty at Rose-Hulman Institute of Technology and Saint Mary-of-the-Woods College will also carry out research using the NMR. This equipment will enable researchers to carry out studies on a) Enantioselective Swern Oxidation of Alcohols; b) Development of Tripodal Amine Ligands for Enantioselective Catalysis; c) Multivalent Ligands for Nicotinic Receptors; d) Bioassay-Guided Isolation, Structure Elucidation, and Synthesis of Neuroactive Compounds; e) Sodium Carbonate/Percarbonate in the Baeyer-Villiger Oxidation; f) Synthesis and Immunological Evaluation of Prenylated Proteins and Carbohydrates; g) New Dinuclear Molybdenum-thiolate Compounds with Multiple Oxidation States; h) Bacterial Classification by Lipid Composition Analysis; i) Total Synthesis of Sattabacin/Sattazolin; and j) Structure and Dynamics of Polycarbonates. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in medicinal chemistry, biochemistry and synthetic chemistry.

在主要研究仪器（MRI）计划的支持下，印第安纳州州立大学化学系将获得一台400 MHz核磁共振（NMR）光谱仪。Rose-Hulman理工学院和Saint Mary-of-the-Woods学院的教师也将使用NMR进行研究。 该设备将使研究人员能够进行以下研究：a）醇的对映选择性Swern氧化; B）用于对映选择性催化的三脚架胺配体的开发; c）烟碱受体的多价配体; d）生物测定引导的神经活性化合物的分离、结构解析和合成; e）Baeyer-Villiger氧化中的碳酸钠/过碳酸钠; f）异戊烯化蛋白质和碳水化合物的合成和免疫学评价; g）具有多种氧化态的新双核钼硫醇化合物; h）通过脂质组成分析的细菌分类; i）Sattabacin/Sattazolin的全合成;和j）聚碳酸酯的结构和动力学。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对药物化学、生物化学和合成化学产生影响。