EAGER: Early Detection of Ovarian Cancer with Polarized Light Scattering Spectroscopy

本EAGER提案的目的是为妇科肿瘤学家提供一种基于光散射光谱（LSS）的诊断筛查工具，使医生能够以微创的方式调查CA-125水平高和/或有卵巢癌家族史的患者的卵巢，并以高概率确定不典型增生或早期癌症的存在。它将在大约一分钟内对卵巢的大部分表面进行测量，并实时显示信息。然后可以对可疑部位进行活检并证实诊断。这种方法应该大大优于目前进行CA-125测试和超声检查的策略。它也将显著提高早期癌症的发现概率，在更有侵入性的随机活检中。因此，它将为筛查卵巢癌高危人群的早期癌前病变提供有力的工具。研究者将收集卵巢恶性和良性离体组织的LSS光谱，以确定不典型增生和早期癌症的光散射光谱特征，并设计诊断算法。他们还将设计和建造带有超声引导极化LSS （PLSS）微创探针的原型临床仪器。

0943180PerelmanThe purpose of this EAGER proposal is to provide the gynecologic oncologist with a light scattering spectroscopy (LSS) based diagnostic screening tool which will enable physicians to survey ovaries in patients with high levels of CA-125 and/or a family history of ovarian cancer in a minimally invasive fashion, and determine with high probability the presence of dysplasia or early cancer. It will perform measurements on most of the surface of the ovary in about one minute and present the information in real time. Suspicious areas can then be biopsied and the diagnosis verified. This approach should be vastly superior to the present strategies of performing a CA-125 test and ultrasound examination. It will also significantly improve the probability of locating early cancer during the significantly more invasive random biopsies. Thus it will provide a powerful tool for screening the population of patients with high ovarian cancer risk factors for early precancerous changes. The investigators will collect LSS spectra from both malignant and benign ex vivo ovarian tissue in order to confirm the light scattering spectral signatures of dysplasia and early cancer and design the diagnostic algorithm. They will alsodesign and build the prototype clinical instrument with an ultrasound guided polarized LSS (PLSS) minimally invasive probe.