EAGER: Early Detection of Ovarian Cancer with Polarized Light Scattering Spectroscopy

0943180 Perelman EAGER的目的是为妇科肿瘤学家提供一种基于光散射光谱（LSS）的诊断筛查工具，该工具将使医生能够以微创的方式调查CA-125水平高和/或有卵巢癌家族史的患者的卵巢，并以高概率确定发育不良或早期癌症的存在。它将在大约一分钟内对卵巢的大部分表面进行测量，并以真实的时间呈现信息。可疑区域可以进行活检，并验证诊断。这种方法应该大大优于目前的策略进行CA-125测试和超声检查上级。它还将显著提高在显著更具侵入性的随机活检期间定位早期癌症的概率。因此，它将提供一个强有力的工具，筛选人群的卵巢癌高危因素的早期癌前病变。研究人员将收集来自恶性和良性离体卵巢组织的LSS光谱，以确认发育不良和早期癌症的光散射光谱特征，并设计诊断算法。他们还将设计和制造带有超声引导极化LSS（PLSS）微创探头的原型临床仪器。

0943180PerelmanThe purpose of this EAGER proposal is to provide the gynecologic oncologist with a light scattering spectroscopy (LSS) based diagnostic screening tool which will enable physicians to survey ovaries in patients with high levels of CA-125 and/or a family history of ovarian cancer in a minimally invasive fashion, and determine with high probability the presence of dysplasia or early cancer. It will perform measurements on most of the surface of the ovary in about one minute and present the information in real time. Suspicious areas can then be biopsied and the diagnosis verified. This approach should be vastly superior to the present strategies of performing a CA-125 test and ultrasound examination. It will also significantly improve the probability of locating early cancer during the significantly more invasive random biopsies. Thus it will provide a powerful tool for screening the population of patients with high ovarian cancer risk factors for early precancerous changes. The investigators will collect LSS spectra from both malignant and benign ex vivo ovarian tissue in order to confirm the light scattering spectral signatures of dysplasia and early cancer and design the diagnostic algorithm. They will alsodesign and build the prototype clinical instrument with an ultrasound guided polarized LSS (PLSS) minimally invasive probe.