Acquisition of a Low-Field NMR Spectrometer for Research and Teaching

新墨西哥大学化学和化学生物学系的Martin L.Kirk、Richard Kemp、Patrick S.Mariano、Robert T.Paine和Wang教授将获得一台低场(300 MHz)多核核磁共振波谱仪。该仪器将用于支持下列研究活动：1)合成方法，允许富含第13、14和15族元素的主族元素环和多环笼状化合物的新家族的逐步(逐个原子)组装；2)活化和固定小分子，如二氧化碳、COS、二硫化碳和氧，以产生更有价值的产品；3)使用后过渡金属钳形络合物，以均相催化路线生成环氧化物和其他部分氧化的有机物；4)合成中间体、天然和非天然产物的结构和立体化学表征；5)蓝氏贾第鞭毛虫生长抑制剂的合理设计和磷蛋白的研究；6)作为分子导线器件潜在组成部分的供体-桥-受体系统的研究；7)胆固醇酯酶、乳酸脱氢酶、NFkB、尿激酶、醛糖还原酶、HIV蛋白酶和Aβ聚合体等蛋白质的新抑制剂的合成。这些光谱使研究人员能够识别未知物质，并通过检测原子的核自旋性质引起的能级之间的跃迁，提供从小分子到大蛋白质的各种物种中的原子排列和结构信息。这台光谱仪将加强研究人员和学生的许多研究活动，他们中的许多人来自代表性不足的群体。

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professors Martin L. Kirk, Richard Kemp, Patrick S. Mariano, Robert T. Paine and Wei Wang from the Department of Chemistry and Chemical Biology at the University of New Mexico will acquire a low-field (300 MHz) multinuclear NMR spectrometer. The instrument will be used to support research activities such as: 1) synthetic methodologies that allow for step by-step (atom-by-atom) assembly of new families of main group element ring and polycyclic cage compounds rich in Group 13, 14 and 15 elements; 2) activation and fixing of small molecules such as carbon dioxide, COS, carbon disulfide, and oxygen to produce more valuable products; 3) homogeneous catalytic routes to epoxides and other partially-oxidized organics using late transition metal pincer complexes; 4) characterization of structures and stereochemistry of synthetic intermediates and natural and non-natural products; 5) rational design of Giardia lamblia growth inhibitors as well as study of phosphoproteins; 6) study of donor-bridge-acceptor systems as potential components of molecular wire devices and, 7) synthesis of new inhibitors of the proteins cholesterol esterase, lactate dehydrogenase, NfKB, urokinase, aldose reductase, HIV protease and Abeta aggregates.Multinuclear NMR spectroscopy is an essential analytical tool in chemistry and biochemistry research. The spectra enable researchers to identify unknown substances and to provide information on the atom arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This spectrometer will enhance many research activities of investigators and students, many of whom are from underrepresented groups.