Agilent 7200 GC/Q-TOF for the University of Utah

 描述(由申请人提供)：本提案是为犹他州大学代谢组学核心设施提供资金的安捷伦7200 GC/Q-TOF质谱仪的申请。该仪器将用于两个主要目的：1)用提供先进研究能力的高性能仪器取代老化、低性能和不可靠的GC-MS；2)每年为大约40个不同的GC-MS用户提高代谢组学核心的样品分析效率和能力。根据GCT Premier最近的使用情况，来自犹他大学的10个主要用户，以及11个NIH资助的有效赠款，已被确定为当前和未来的研究项目，这些项目确保了安捷伦7200的立即和长期继续使用。所有这些用户都与代谢组学核心有着长期的历史，利用核心的GC-MS能力来促进他们由NIH资助的研究。目前的GC-MS仪器已经发表了超过32篇论文，其中许多发表在影响较大的期刊上，包括《科学》、《美国国家科学院院刊》、《细胞代谢》和《自然细胞生物学》。安捷伦7200 GC/Q-TOF是一款高性能质谱仪，具有高灵敏度、高同位素准确度、宽动态范围以及代谢组学和通量组学分析所需的多功能性。此外，该仪器操作简单，只需要很少的培训。新陈代谢核心目前拥有和运营另外四台安捷伦仪器，其中三台仪器的操作软件和数据分析软件是相同的。7200 GC/Q-TOF将被安置在代谢组学核心，该核心位于主要用户的中央位置。代谢组学核心由研究所管理，在结构良好的核心研究设施框架内，包括监督和咨询委员会。有非常强大的机构财政支持，以确保仪器的长期使用，包括服务协议和操作仪器的全职博士质谱学家。对犹他大学和地区机构的长期影响将是最先进的马质谱计，以促进NIH资助的研究人员的目标。核心已经有很长的历史，最大限度地利用目前的GC-MS仪器，以帮助在新陈代谢、癌症研究和微生物组领域的重要发现。

 DESCRIPTION (provided by applicant): This proposal is a request for funding for an Agilent 7200 GC/Q-TOF mass spectrometer for the University of Utah Metabolomics Core Facility. The instrument will serve two primary purposes: 1) replace an aging, lower performance and unreliable GC-MS with a high performance instrument that provides advanced research capabilities, and 2) increase sample analysis efficiency and capacity for the Metabolomics Core for the approximately 40 different users of GC-MS, annually. Based upon recent use of the GCT Premier 10 major users from the University of Utah, with 11 active NIH- funded grants, have been identified with current and future research projects, which ensure immediate and long-term continued use of the Agilent 7200. All of these users have a long term history with the Metabolomics Core, leveraging the Core's GC-MS capabilities to further their NIH funded research. The current GC-MS instrumentation has contributed to over 32 publications, many in high impact journals including Science, PNAS, Cell Metabolism, and Nature Cell Biology. The Agilent 7200 GC/Q-TOF is a high-performance mass spectrometer that provides the high sensitivity, high isotope accuracy, wide dynamic range, and the versatility needed for metabolomics and fluxomics analysis. In addition, this instrument is easy to operate and will require minimal training. The Metabolomics Core currently owns and operates four other Agilent instruments, the operating software as well as the data analysis software are the same across three out of four of these instruments. The 7200 GC/Q-TOF will be housed in the Metabolomics Core which is centrally located to the major users. The Metabolomics Core is administered by the Institution, within a well-structured Core Research Facilities framework, including Oversight and Advisory committees. There is very strong Institutional financial support to ensure long-term utilization of the instrument, including service agreements and full-time Ph.D. mass spectrometrists to operate the instrument. The long-term impact to the University of Utah and the regional institutions will be a state of the art work horse mass spectrometer to further the goals of the NIH funded researchers. The Core has a long history of maximizing the current GC-MS instrumentation to aid in important discoveries in the field of metabolism, cancer research, and the microbiome.