Agilent 7200 GC/Q-TOF for the University of Utah

 描述（由申请人提供）：本提案是为犹他州大学代谢组学核心设施的Agilent 7200 GC/Q-TOF质谱仪提供资金的申请。该仪器将用于两个主要目的：1）用提供先进研究能力的高性能仪器取代老化、性能较低和不可靠的GC-MS，2）每年为大约40个不同的GC-MS用户提高代谢组学核心的样品分析效率和容量。根据最近对GCT Premier的使用情况，已确定犹他州大学的10个主要用户参与当前和未来的研究项目，其中11个获得了NIH资助的赠款，这些项目确保了Agilent 7200的立即和长期持续使用。所有这些用户都有长期使用代谢组学核心的历史，利用核心的GC-MS功能来进一步推动他们的NIH资助的研究。目前的GC-MS仪器已经发表了超过32篇论文，其中许多发表在高影响力的期刊上，包括Science，PNAS，Cell Metabolism和Nature Cell Biology。Agilent 7200 GC/Q-TOF是一款高性能质谱仪，可提供代谢组学和通量组学分析所需的高灵敏度、高同位素准确度、宽动态范围和多功能性。此外，该仪器易于操作，只需要很少的培训。Metabolomics Core目前拥有并运营着另外四台安捷伦仪器，其中三台仪器的操作软件和数据分析软件是相同的。7200 GC/Q-TOF将安置在代谢组学核心中，位于主要用户的中心位置。代谢组学核心由该机构管理，在结构良好的核心研究设施框架内，包括监督和咨询委员会。有非常强大的机构财政支持，以确保长期使用的工具，包括服务协议和全职博士学位。质谱仪操作仪器。对犹他州大学和区域机构的长期影响将是一个最先进的工作马质谱仪，以进一步实现NIH资助的研究人员的目标。Core在最大化当前GC-MS仪器以帮助代谢、癌症研究和微生物组领域的重要发现方面有着悠久的历史。

 DESCRIPTION (provided by applicant): This proposal is a request for funding for an Agilent 7200 GC/Q-TOF mass spectrometer for the University of Utah Metabolomics Core Facility. The instrument will serve two primary purposes: 1) replace an aging, lower performance and unreliable GC-MS with a high performance instrument that provides advanced research capabilities, and 2) increase sample analysis efficiency and capacity for the Metabolomics Core for the approximately 40 different users of GC-MS, annually. Based upon recent use of the GCT Premier 10 major users from the University of Utah, with 11 active NIH- funded grants, have been identified with current and future research projects, which ensure immediate and long-term continued use of the Agilent 7200. All of these users have a long term history with the Metabolomics Core, leveraging the Core's GC-MS capabilities to further their NIH funded research. The current GC-MS instrumentation has contributed to over 32 publications, many in high impact journals including Science, PNAS, Cell Metabolism, and Nature Cell Biology. The Agilent 7200 GC/Q-TOF is a high-performance mass spectrometer that provides the high sensitivity, high isotope accuracy, wide dynamic range, and the versatility needed for metabolomics and fluxomics analysis. In addition, this instrument is easy to operate and will require minimal training. The Metabolomics Core currently owns and operates four other Agilent instruments, the operating software as well as the data analysis software are the same across three out of four of these instruments. The 7200 GC/Q-TOF will be housed in the Metabolomics Core which is centrally located to the major users. The Metabolomics Core is administered by the Institution, within a well-structured Core Research Facilities framework, including Oversight and Advisory committees. There is very strong Institutional financial support to ensure long-term utilization of the instrument, including service agreements and full-time Ph.D. mass spectrometrists to operate the instrument. The long-term impact to the University of Utah and the regional institutions will be a state of the art work horse mass spectrometer to further the goals of the NIH funded researchers. The Core has a long history of maximizing the current GC-MS instrumentation to aid in important discoveries in the field of metabolism, cancer research, and the microbiome.