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The dictionary of genetic effects and the language of morphology

遗传效应词典和形态学语言

基本信息

批准号：
0950002
负责人：
David Houle
金额：
$ 75万
依托单位：
Florida State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0950002&HistoricalAwards=false
关键词：
dictionary genetic effects language morphology

项目摘要

The success of genome-sequencing projects highlights how little we know about how the whole organism is put together. Deciphering the relationship between the genome and the organism requires study of the effects of subtle genetic changes on the whole organism. This project will develop and apply one such approach by manipulating the expression of hundreds of genes and observing the effects on body shape, then using modeling to test understanding of how these effects occur. The project will focus on the genetic basis of shape of the wing of fruit flies, one of the few multi-cellular organisms where the necessary genetic manipulations are easy to accomplish and detailed data can be obtained in large quantities. This project has broad significance for biology, because health and disease in humans, improvement of domesticated plants and animals, and the ability of organisms to adapt, all derive from the relationship between the genome and the organism. This project will provide more detailed data on the genetic basis of variation in the whole organism than has previously been available. The research will provide a procedural model and analytical software which can be used by others to extend such studies to other organisms and that ultimately is applicable to humans and the species we interact with. Many undergraduates and a post-doctoral research will receive training through participation in this project.

基因组测序项目的成功凸显了我们对整个有机体是如何组合在一起的知之甚少。破译基因组和生物体之间的关系需要研究微妙的遗传变化对整个生物体的影响。该项目将通过操纵数百个基因的表达并观察对体型的影响，然后使用建模来测试对这些影响如何发生的理解，来开发和应用这样一种方法。该项目将侧重于果蝇翅膀形状的遗传基础，果蝇是少数几种容易完成必要遗传操作并可获得大量详细数据的多细胞生物之一。这个项目对生物学有着广泛的意义，因为人类的健康和疾病，驯化植物和动物的改进，以及生物体的适应能力，都源于基因组和生物体之间的关系。该项目将提供比以往更详细的关于整个生物体变异遗传基础的数据。该研究将提供一个程序模型和分析软件，可供其他人使用，将此类研究扩展到其他生物体，最终适用于人类和与我们互动的物种。许多本科生和博士后研究将通过参与该项目接受培训。