Integrated analyses of the seasonally quiescent ovary and female reproductive aging

卵巢季节性静止与女性生殖衰老的综合分析

• 批准号: 0950650
• 负责人: Ned Place
• 金额: $ 24.68万
• 依托单位: Cornell Univ - State: AWDS MADE PRIOR MAY 2010
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0950650&HistoricalAwards=false
• 关键词: Integrated; analyses; seasonally; quiescent; ovary

Terms such as quiescent, inhibited, and inactive are often used to describe the state of the ovaries in seasonally breeding mammals when considered outside of the breeding season. However, recent findings have demonstrated important structural and functional changes in the so-called quiescent ovary that appear to modulate the reproductive aging process. More specifically, maintaining female Siberian hamsters in short photoperiod is associated with profound changes of the ovary that appear to manifest as decelerated reproductive aging. The outcomes of the short-day-induced changes include improved fertility and a preservation of ovarian follicles in older females. Therefore, the cessation of ovulatory activity under conditions that do not favor breeding should not be equated with ovarian inactivity. This research project will transform and inform our thinking about the seasonally quiescent ovary and provide a better understanding of its role in reproductive aging. Integrative analyses will determine if and how photoperiod-induced changes in hormone secretion from the pituitary gland contribute to the development of the short-day ovarian phenotype. Because melatonin, a hormone secreted by the pineal gland, mediates the effects of short photoperiod in seasonally breeding mammals, research will determine if the absence of melatonin is associated with an acceleration of ovarian aging. The broader impact of this research lies in its inclusion of trainees in all aspects of the investigation, with a special effort made to attract women and underrepresented minorities to the lab. The results of our experiments will be of interest to a broad array of scientists, including reproductive biologists, ecologists, chronobiologists, and gerontologists. Because there is a continuing trend for women to delay having their first child until an advanced reproductive age, our results may have important implications for society, as insights into female reproductive aging may be applicable to all mammalian species, including our own.

术语如静止，抑制和不活跃通常用于描述季节性繁殖哺乳动物在繁殖季节之外的卵巢状态。然而，最近的研究结果表明，在所谓的静止卵巢，似乎调节生殖衰老过程中的重要结构和功能的变化。更具体地说，保持雌性西伯利亚仓鼠在短的光周期与卵巢的深刻变化，似乎表现为减速生殖老化。短日照引起的变化的结果包括提高生育能力和保护老年女性的卵泡。因此，在不利于繁殖的条件下停止排卵活动不应等同于卵巢不活动。这项研究项目将改变和告知我们对季节性静止卵巢的思考，并更好地了解其在生殖衰老中的作用。综合分析将确定光周期诱导的垂体激素分泌变化是否以及如何促进短日照卵巢表型的发展。由于褪黑激素，一种由松果体分泌的激素，介导了季节性繁殖哺乳动物的短光周期效应，研究将确定褪黑激素的缺乏是否与卵巢老化的加速有关。这项研究的更广泛影响在于它将受训人员纳入调查的各个方面，并特别努力吸引妇女和代表性不足的少数民族进入实验室。我们的实验结果将引起广泛的科学家的兴趣，包括生殖生物学家，生态学家，时间生物学家和老年学家。由于女性推迟生育第一个孩子的趋势持续存在，直到生育年龄提前，我们的研究结果可能对社会产生重要影响，因为对女性生殖年龄的见解可能适用于所有哺乳动物物种，包括我们自己。