RUI: Interdependence of Nutrient and Pheromone Sensing Pathways in Yeast

RUI:酵母中营养物质和信息素传感途径的相互依赖性

基本信息

  • 批准号:
    0952519
  • 负责人:
  • 金额:
    $ 43.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-03-01 至 2013-05-31
  • 项目状态:
    已结题

项目摘要

Cell division and fusion are resource intensive activities, and thus the ability of the yeast cell to coordinate the availability of nutrients in its environment with reproduction is of great physiological importance. This project will examine the role that glucose availability plays in yeast mating by testing the hypothesis that glucose sensing and mating are interdependent. The glucose sensor and the pheromone receptor are the only G protein coupled receptors (GPCR) in yeast. The aims of this project include 1) assessing the effects of pheromone stimulation on the glucose sensor, 2) examining the direct physical interactions of the glucose sensing and pheromone receptors, and 3) identifying interactions between components of the signaling pathways downstream of these receptors. Broader Impacts: This project, while enhancing our understanding of the relationship between nutrient sensing and mating in yeast, will impact undergraduate students and the science faculty at three primarily undergraduate institutions. Undergraduate students will be exposed to biochemical research during an intensive ten week summer project, with the opportunity to continue their research during the academic year. These students will be involved in the design, implementation, interpretation, and dissemination of the results of their own experiments in a community of their peers. This project represents an opportunity for the investigators to integrate their research into their teaching, thereby enhancing the scientific education of hundreds of students at the participating institutions. The students involved in this research will be primarily from a typically underserved population (including under-represented minorities) in rural Appalachia.
细胞分裂和融合是资源密集型活动,因此酵母细胞协调环境中营养物质的利用和繁殖的能力具有重要的生理意义。这个项目将通过测试葡萄糖感应和交配是相互依赖的假设来检验葡萄糖可用性在酵母交配中所起的作用。葡萄糖感受器和信息素受体是酵母中仅有的G蛋白偶联受体。该项目的目的包括1)评估信息素刺激对葡萄糖感受器的影响,2)检测葡萄糖感受器和信息素受体之间的直接物理相互作用,以及3)识别这些受体下游信号通路组件之间的相互作用。更广泛的影响:这个项目在加强我们对酵母中营养感应和交配之间关系的理解的同时,将影响本科生和三个主要本科院校的理科教师。本科生将在为期十周的密集暑期项目中接触到生化研究,并有机会在学年继续他们的研究。这些学生将参与设计、实施、解释和传播他们自己在同龄人社区中的实验结果。这一项目为研究人员提供了一次机会,将他们的研究融入到他们的教学中,从而加强参与机构对数百名学生的科学教育。参与这项研究的学生将主要来自阿巴拉契亚农村地区典型的未得到充分服务的人群(包括未被充分代表的少数民族)。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Stephen Wright其他文献

On a mission.
在执行任务。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Wright
  • 通讯作者:
    Stephen Wright
A Study into Certain Aspects of the Cost of Capital for Regulated Utilities in the U.K.
英国受监管公用事业公司资本成本某些方面的研究
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Wright;R. Mason;D. Miles
  • 通讯作者:
    D. Miles
Lyme disease in the UK: clinical and laboratory features and response to treatment
  • DOI:
    10.7861/clinmedicine.10-5-454
  • 发表时间:
    2010-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Richard Dillon;Susan O’Connell;Stephen Wright
  • 通讯作者:
    Stephen Wright
Novel hyperbranched polymers from transfer-dominated branching radical telomerisation (TBRT) of diacrylate taxogens
新型超支化聚合物来自二丙烯酸酯类紫杉烷前体的转移主导支化自由基端基聚合(TBRT)
  • DOI:
    10.1039/d5py00062a
  • 发表时间:
    2025-02-21
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Samuel Mckeating;Corinna Smith;Oliver Penrhyn-Lowe;Sean Flynn;Stephen Wright;Pierre Chambon;Andrew Dwyer;Steve Rannard
  • 通讯作者:
    Steve Rannard
Internalism in the Epistemology of Testimony
  • DOI:
    10.1007/s10670-015-9729-y
  • 发表时间:
    2015-03-05
  • 期刊:
  • 影响因子:
    0.900
  • 作者:
    Stephen Wright
  • 通讯作者:
    Stephen Wright

Stephen Wright的其他文献

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{{ truncateString('Stephen Wright', 18)}}的其他基金

AF: Small: Bridging the Past and Present of Continuous Optimization for Learning
AF:小:连接持续优化学习的过去和现在
  • 批准号:
    2224213
  • 财政年份:
    2022
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
TRIPODS: Institute for Foundations of Data Science
TRIPODS:数据科学研究所
  • 批准号:
    2023239
  • 财政年份:
    2020
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Continuing Grant
TRIPODS: Institute for Foundations of Data Science
TRIPODS:数据科学研究所
  • 批准号:
    1740707
  • 财政年份:
    2017
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
Extending Sparse Optimization
扩展稀疏优化
  • 批准号:
    1216318
  • 财政年份:
    2012
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
US-Mexico Workshop on Optimization and its Applications
美国-墨西哥优化及其应用研讨会
  • 批准号:
    1031095
  • 财政年份:
    2010
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
International Symposium on Mathematical Programming 2009; Chicago, IL; August 2009
2009年数学规划国际研讨会;
  • 批准号:
    0937025
  • 财政年份:
    2009
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
Sparse and Regularized Optimization
稀疏和正则优化
  • 批准号:
    0914524
  • 财政年份:
    2009
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
Nonlinear Optimization: Algorithms, Software, Applications
非线性优化:算法、软件、应用
  • 批准号:
    0430504
  • 财政年份:
    2004
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
Collaborative Research: MW: Master-Worker Middleware for Grids
合作研究:MW:网格主从中间件
  • 批准号:
    0330538
  • 财政年份:
    2003
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Standard Grant
C-RUI: Development and Applications of a Novel Biosensor
C-RUI:新型生物传感器的开发与应用
  • 批准号:
    0216716
  • 财政年份:
    2002
  • 资助金额:
    $ 43.91万
  • 项目类别:
    Continuing Grant

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