MRI-R2: Acquisition of a Nanotom-Computed Tomography System for Revolutionizing Metallic Biomaterials Research, Education and Training

MRI-R2：购买纳米计算机断层扫描系统，彻底改变金属生物材料研究、教育和培训

• 批准号: 0959511
• 负责人: Jagannathan Sankar
• 金额: $ 68.29万
• 依托单位: North Carolina Agricultural & Technical State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959511&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Nanotom; Computed

0959511SankarThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Computed tomography (CT) is the 3D-reconstruction of projections of an object viewed from different directions. CT non-destructively generates a fully 3D model of samples that allows many possibilities for analysis: the non-destructive visualization of slices (a very powerful aspect), arbitrary sectional views, pseudo-color representations and pore analysis. Technological advances have led to progressive improvements in CT resolution and accuracy. In the past, synchrotron radiation-based microCT (SRìCT) has been the high resolution technique of choice. Nanotomography (nanoCT), a recently developed technique, exploits X-ray sources with sub-ìm focal spot size to yield spatial resolutions down to 200-300 nm. NanoCT enables a large range of applications ranging from low-absorbing biological samples to high-absorbing metal objects such as metallic implant materials. The proposed system provides room for future expansion to design and incorporate appropriate accessories for high-resolution in situ visualization of material behavior in in vivo environmental conditions, as dictated by research findings. The vision of NCAT's NSF ERC-RMB is to revolutionize metallic biomaterials and underlying sciences and technologies, leading to engineered systems that will interface with the human body to prolong and improve quality of life, coupled with the development of a vibrant, diverse workforce well-prepared for the multidisciplinary and global challenges and opportunities of the new millennium. The mission is to deliver on the potential of bio/nanoengineering to dramatically improve treatments for orthopedic, craniofacial and cardiovascular ailments. The goal is to develop new implant materials and tunable biodegradable metals that can grow and adapt to the human body and eventually dissolve when no longer needed.

0959511 Sankar该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。计算机断层扫描（CT）是从不同方向观察物体投影的3D重建。CT非破坏性地生成样品的全3D模型，允许多种分析可能性：切片的非破坏性可视化（非常强大的方面）、任意截面视图、伪彩色表示和孔隙分析。技术进步导致CT分辨率和准确性的逐步提高。在过去，基于同步辐射的microCT（SRECT CT）一直是首选的高分辨率技术。纳米断层扫描（nanoCT）是最近开发的技术，其利用具有亚微米焦斑尺寸的X射线源来产生低至200-300 nm的空间分辨率。NanoCT能够实现从低吸收生物样品到高吸收金属物体（如金属植入材料）的广泛应用。所提出的系统提供了空间，未来的扩展，设计和纳入适当的配件，在体内环境条件下的材料行为的高分辨率原位可视化，所指示的研究结果。NCAT的NSF ERC-RMB的愿景是彻底改变金属生物材料和基础科学和技术，导致工程系统，将与人体接口，以延长和提高生活质量，再加上一个充满活力的，多样化的劳动力的发展，为新千年的多学科和全球挑战和机遇做好充分准备。该研究所的使命是发挥生物/纳米工程的潜力，极大地改善骨科、颅面和心血管疾病的治疗。目标是开发新的植入材料和可调的可生物降解金属，这些金属可以生长和适应人体，并最终在不再需要时溶解。