EAGER: Nanostructured porous and laminate coatings for biodegradable magnesium-based implants with tunable water permeability and improved mechanical properties

可生物降解的镁基合金被认为是一种很好的植入材料，不需要额外的二次手术来取出种植体。它们重量轻，具有接近骨骼的物理机械性能，良好的生物相容性和骨整合，可以完全降解并被自然再生的骨骼取代。然而，裸露的镁基种植体的安装经常伴随着较高的初始腐蚀率和氢气释放，这会导致各种术后并发症。因此，它们的成功实施在很大程度上取决于腐蚀速度和氢气释放的控制，特别是在安装初期。这种功能可以通过具有良好控制的透水性的特殊涂层来提供。该项目支持对可生物降解镁植入物的探索性工作，该想法未经测试，但具有潜在的变革性。该公司正在探索一种新的工艺方法和基本机制，即通过能够提供定向/可调再吸收或降解时间的涂层组件，实现新的“用于可调水传输的薄膜涂层概念”。它将研究如何将薄的、可降解的和纳米孔层结合到纳米层涂层中，从而显著扩展对镁基植入物初始腐蚀速度的可调控制。该项目还支持为HBCU的URM学生提供最先进的科学和技术培训，以及更深入地接触基于团队的研究和创造价值的最佳实践。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Biodegradable Mg-based alloys are considered as a great material for implantation without additional secondary surgery for implant removal. They are lightweight, have close to bones physical and mechanical properties, excellent biocompatibility and osseointegration, and they can completely degrade and be replaced by naturally re-grown bones. However, installation of bare Mg-based implants has frequently been accompanied with high initial corrosion rate and hydrogen release burst that can cause variety of post-surgical complications. Therefore, the success of their implementation highly depends on control of corrosion rate and hydrogen release especially during the initial stage of installation. This function can be provided by special coatings having well-controlled water permeability. This project supports exploratory work on an untested, but potentially transformative idea for biodegradable Mg implants. It is exploring a new process methodology and underlying mechanism in a new "thin film coatings concept for tunable water transport" - through coating components that are capable of providing targeted/tunable resorption or degradation time. It will study how combining thin, degradable and nanoporous layers into nanolaminate coatings can significantly extend tunable control of initial corrosion rate of Mg-based implants. This project also supports providing URM students at an HBCU with state-of-the-art science and technology training, along with deeper exposure to team-based research and value-creation best practices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.