MRI: Acquisition of Integrated Research Instrument for Large Animal Testing Investigation

Sankar 1229392本提案要求资助适合“大型”动物试验和生物植入材料表征的仪器。他们特别考虑了一种具有XRF功能的HR微型ct和一种多光子共聚焦显微镜。这两件是串联使用，以完全成像全身动物模型。所要求的能力将使动物显微手术，体内实时3D监测和体内成像，以评估深层组织。植入物将被设计成在需要时提供最佳治疗，在不再需要时生物溶解。这些创新将特别有利于儿童腭裂患者、长骨角度畸形、肢体长度差异或创伤，包括需要用针和螺钉修复的骨折。其他应用领域包括老龄化婴儿潮一代的骨质疏松性脆性骨折（手腕，臀部和脊柱）和多肋骨骨折（创伤）的重建。

ABSTRACT Sankar 1229392This proposal is requesting funding for instrumentation suitable for 'large' animal testing and characterization of bio-implant materials. They are specifically considering a HR micro-CT with XRF feature and a multi-photon confocal microscope. These two pieces are used in tandem to completely image whole bady animal models. The requested capability will enable Micro-surgery in animals, in vivo real-time 3D monitoring and in vivo imaging, for evaluating deep tissue. The implants will be designed to provide optimum therapy when required and to bio-dissolve when no longer needed. Such innovations would particularly benefit pediatric cleft palate patients, angular deformities of long bones, limb length discrepancies, or trauma including fractures that require pins and screws for repair. Other areas of application include osteoporotic fragility fractures in aging baby boomers (wrist, hip and spine) and reconstruction of multiple rib fractures (trauma).