MRI: Acquisition of Integrated Research Instrument for Large Animal Testing Investigation

MRI：采购用于大型动物测试研究的综合研究仪器

• 批准号: 1229392
• 负责人: Jagannathan Sankar
• 金额: $ 111.28万
• 依托单位: North Carolina Agricultural & Technical State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229392&HistoricalAwards=false
• 关键词: MRI; Acquisition; Integrated; Research; Instrument

ABSTRACT Sankar 1229392This proposal is requesting funding for instrumentation suitable for 'large' animal testing and characterization of bio-implant materials. They are specifically considering a HR micro-CT with XRF feature and a multi-photon confocal microscope. These two pieces are used in tandem to completely image whole bady animal models. The requested capability will enable Micro-surgery in animals, in vivo real-time 3D monitoring and in vivo imaging, for evaluating deep tissue. The implants will be designed to provide optimum therapy when required and to bio-dissolve when no longer needed. Such innovations would particularly benefit pediatric cleft palate patients, angular deformities of long bones, limb length discrepancies, or trauma including fractures that require pins and screws for repair. Other areas of application include osteoporotic fragility fractures in aging baby boomers (wrist, hip and spine) and reconstruction of multiple rib fractures (trauma).

摘要Sankar 1229392该提案要求为适用于“大型”动物试验和生物植入材料表征的仪器提供资金。他们特别考虑使用具有XRF功能的HR micro-CT和多光子共聚焦显微镜。这两件作品是串联使用，以完整的图像整个bady动物模型。所要求的能力将使动物显微手术，体内实时3D监测和体内成像，用于评估深部组织。植入物的设计将在需要时提供最佳治疗，并在不再需要时进行生物溶解。这些创新将特别有利于儿童腭裂患者，长骨的角度畸形，肢体长度差异，或创伤，包括骨折，需要钉和螺钉进行修复。其他应用领域包括婴儿潮一代老年人（手腕，臀部和脊柱）的骨质疏松性脆性骨折和多根肋骨骨折（创伤）的重建。