Renovation and Modernization of the Center for Interdisciplinary Molecular Biology Education, Research and Advancement at California State University, Sacramento

该奖项是根据2009年美国复苏和再投资法案(公法111-5)资助的。跨学科分子生物学教育、研究和促进中心(Cimera)是由萨克拉门托加州州立大学生物科学系和化学系的教职员工共享的研究设备设施。西梅拉住在红杉大厅地下室的一个有八个房间的套房里，最初是作为动物护理设施而建的。该套间最初的设计限制了其作为细胞和分子生物学实验室的用途。最近为更多的细胞分析和细胞培养设备提供的资金，以及最近扩大的学生/教师研究和研究培训活动，都需要扩大和更新该设施。提供了资金，使西梅拉设施得以扩大和现代化。翻修工程包括(1)拆除焚化炉、不同寻常的地板和阁楼、高压灭菌器和笼式洗涤器，以增加空间，以便扩大细胞分析实验室和哺乳动物和细菌细胞培养实验室；(2)将天花板、照明、地板、电力服务和网络连接更新为适合现代分子细胞生物学实验室的标准；(3)更新长凳、橱柜和管道，以用作分子细胞生物学实验室。这些改造将创建：一个现代化的细胞分析实验室，一个扩大的哺乳动物细胞培养实验室，一个大型设备室，一个细菌细胞培养实验室，以及一个现代化的分子生物学实验室。该设施提供基础细胞培养、分子生物学和细胞分析设备，支持16名教师的研究计划，解决基本问题，如脊椎动物卵子受精的分子事件、载脂蛋白A-I的结构和功能、胚胎发育过程中的细胞分化以及法医DNA分析的基本技术。此外，该设施还支持五个不同的研究培训计划，其中几个是针对代表不足的群体，为本科生和硕士水平的学生提供独立或半独立的研究体验。这些改造将加强参与教职员工的研究计划和对他们学生的培训，从而有能力为大约20名额外的学生提供研究经验。这个项目将推进个别教员的研究项目，解决蛋白质生物化学、分子和细胞生物学以及法医分子生物学的基本问题。此外，改造还将通过提供现代分子和细胞生物学设备设施，加强本科生和硕士生的研究培训。它将通过向萨克拉门托州立大学任职人数不足的群体的学生提供具体的研究培训经验并从当地社区大学转学，增加代表性不足群体对科学的参与。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Center for Interdisciplinary Molecular Biology Education, Research and Advancement (CIMERA) is a research equipment facility shared among faculty from the departments of Biological Sciences and Chemistry at California State University, Sacramento. CIMERA is housed in an eight-room suite in the basement of Sequoia Hall originally built as an animal care facility. The original design of the suite limits its utility as a cell and molecular biology laboratory. Recent funding for additional cell analysis and cell culture equipment, and recent expansion of student/faculty research and research training activities, necessitates expanding and updating the facility. Funds are provided to allow the CIMERA facility to expand and modernize. The renovation involves (1) removing an incinerator, unusual floor and loft, autoclave and cage washer to generate additional space to allow expansion of the cell analysis and mammalian and bacterial cell culture laboratories, (2) updating the ceiling, lighting, flooring, electrical service and network connectivity to a standard appropriate for a modern molecular cell biology laboratory and (3) updating the benches, cabinetry and plumbing for use as a molecular cell biology laboratory. These renovations will create: a modern cell analysis laboratory, an expanded the mammalian cell culture laboratory, a large equipment room, a bacterial cell culture laboratory, and a modernization of the molecular biology laboratory. The facility provides basic cell culture, molecular biology and cell analysis equipment that support the research programs of 16 faculty, addressing fundamental problems such as the molecular events of vertebrate egg fertilization, the structure and function of apolipoprotein A-I, cellular differentiation during embryogenesis and fundamental techniques in forensic DNA analysis. In addition, the facility supports five different research training programs, several of which are targeted at underrepresented groups that provide undergraduate and Master's-level students with independent or semi-independent research experiences. These renovations will enhance the research programs of participating faculty and the training of their students, resulting in the ability to provide research experiences for approximately 20 additional students. This project will advance individual faculty research programs addressing fundamental problems in protein biochemistry, molecular and cell biology and forensic molecular biology. Furthermore, the renovation will enhance the research training of undergraduate and Master's level students by providing a modern molecular and cell biology equipment facility. It will increase the involvement of underrepresented groups in the sciences by providing specific research training experiences to students from underrepresented groups at Sacramento State and transferring from local community colleges.