Infrastructure to Advance Life Sciences in the Ocean State

推进海洋州生命科学的基础设施

• 批准号: 1004057
• 负责人: Geoffrey Bothun
• 金额: $ 2000万
• 依托单位: University of Rhode Island
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1004057&HistoricalAwards=false
• 关键词: Infrastructure; Advance; Life; Sciences; Ocean

Proposal Number: EPS-1004057 Proposal Title: Infrastructure to Advance Life Sciences in the Ocean StateInstitution: University of Rhode IslandThe Rhode Island Research Infrastructure Improvement (RII) program focuses on cutting edge research to understand how marine biological organisms are affected by variations in their surroundings due to climate change effects. The goals of the project are to advance Rhode Island's competitiveness in marine life science, foster collaboration among researchers and educators in the state, and build diverse, well-trained workforce teams involving nine institutions of higher education across the state. This project is regionally relevant, nationally significant, takes advantage of unique Rhode Island resources including the Narragansett Bay, and aligns well with the state Science and Technology plan.Intellectual MeritA number of studies predict that with ocean warming and acidification, many single and multiple cell organisms will be under stress whereas many pathogenic microbes and parasites will thrive. The resilience of marine organisms to climate change will depend crucially on acclimation and adaptation. The Rhode Island RII program is aimed at understanding, predicting, and mitigating the impacts of environmental stresses on marine organisms and ecosystems. These studies are fundamentally important to the global biosphere (and locally to Narragansett Bay) as nutrient cycles and sustained biological production in the ocean, ultimately determine the availability of seafood. The investigations focus on key individual organisms (e.g., fish, plankton, marine pathogens), food webs, and the spread of infection and disease among marine host populations. The studies will explore how these species are affected by changes in chemical and physical parameters in the ocean such as temperature, acidity, and nutrient availability. Through these activities, the researchers at Rhode Island will be well positioned to make significant intellectual contribution to the assessment of climate change effects on marine organisms and ecosystems.Broader ImpactsThe infrastructure improvements for life sciences research and education and the partnership among public and private institutions of higher education including two- and four-year colleges will assist in building Rhode Island's research capacity. The Rhode Island EPSCoR Academy will coordinate efforts to foster collaboration among diverse institutions, broaden participation to increase diversity, and engage students at all levels in research and educational training. Fellowships for students and programs aimed at increasing the participation of under-represented minority groups are included in this RII project. A unique aspect of this project is the involvement of Rhode Island School of Design (RISD) for interdisciplinary collaboration among scientists and RISD artists and designers. This interaction is expected to enable the development of improved tools and strategies for the visualization and communication of complex scientific information to K-12 students and non-traditional audiences. In addition, collaborations with the University of Rhode Island's Metcalf Institute will enhance science communication by strengthening interaction among scientists, students, and journalists.

提案编号：EPS-1004057提案标题：基础设施，以促进生命科学在海洋国家机构：罗德岛大学的罗得岛研究基础设施改善（RII）计划的重点是尖端研究，以了解海洋生物有机体是如何受到影响的变化，在他们的周围环境，由于气候变化的影响。该项目的目标是提高罗得岛在海洋生物科学方面的竞争力，促进该州研究人员和教育工作者之间的合作，并建立涉及全州9所高等教育机构的多样化，训练有素的劳动力队伍。这个项目是区域相关的，全国性的重大，利用独特的罗得岛资源，包括纳拉甘塞特湾的优势，并与国家科学和技术计划。智力MeritA一些研究预测，随着海洋变暖和酸化，许多单细胞和多细胞生物将处于压力之下，而许多病原微生物和寄生虫将茁壮成长。海洋生物对气候变化的适应能力将在很大程度上取决于驯化和适应。罗得岛RII计划旨在了解、预测和减轻环境压力对海洋生物和生态系统的影响。这些研究对全球生物圈（以及当地的纳拉甘塞特湾）至关重要，因为海洋中的营养循环和持续的生物生产最终决定了海产品的供应。调查重点是关键的个体生物（例如，鱼类、浮游生物、海洋病原体）、食物网以及感染和疾病在海洋宿主种群中的传播。这些研究将探讨这些物种如何受到海洋中化学和物理参数变化的影响，如温度，酸度和营养物质的可用性。通过这些活动，罗得岛的研究人员将处于有利地位，为评估气候变化对海洋生物和生态系统的影响作出重大的智力贡献。更广泛的影响生命科学研究和教育的基础设施的改善以及包括两年制和四年制学院在内的公立和私立高等教育机构之间的伙伴关系将有助于建立罗得岛的研究能力。在罗得岛EPSCoR学院将协调努力，促进不同机构之间的合作，扩大参与，以增加多样性，并在研究和教育培训的各级学生。该RII项目包括学生奖学金和旨在增加代表性不足的少数群体参与的方案。这个项目的一个独特的方面是罗得岛设计学院（RISD）的科学家和RISD艺术家和设计师之间的跨学科合作的参与。这种互动预计将使改进的工具和战略的可视化和复杂的科学信息的K-12学生和非传统观众的沟通发展。此外，与罗得岛大学梅特卡夫研究所的合作将通过加强科学家、学生和记者之间的互动来加强科学传播。

项目成果

Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers

使用自组装混合脂质层调节氧化铁纳米颗粒的多功能性

• DOI: 10.1021/acs.bioconjchem.7b00483
• 发表时间: 2017
• 期刊: Bioconjugate Chemistry
• 影响因子: 4.7
• 作者: Preiss, Matthew R.;Cournoyer, Eily;Paquin, Karissa L.;Vuono, Elizabeth A.;Belanger, Kayla;Walsh, Edward;Howlett, Niall G.;Bothun, Geoffrey D.
• 通讯作者: Bothun, Geoffrey D.