Multifunctional and Stimuli-Responsive Core-Shell Nanoparticles Based on Liposome Templating

1337061PI：Bothun将创建一个通用的过程，其中将使用小的脂质双层囊泡或脂质体作为生物兼容模板，以创建具有不同核和壳形态的磁性金核-壳纳米颗粒。核壳纳米粒子将提供一种结构，其中磁核对永久磁场或交变射频(RF)电磁场做出响应，而金壳对紫外线-可见光或近红外(NIR)光做出光子学响应。RF和NIR吸光度将作为核壳结构的函数进行检查，包括球形和管状几何结构。通过利用核壳纳米颗粒将吸收的场能转化为热能的能力，将研究使用双重近红外和射频触发器的脂质体模板纳米颗粒的控制释放。这一方法代表了一种原创性的战略，该项目有望在多功能纳米颗粒的合成方法以及纳米颗粒对同时的近红外和射频场的响应和反应方式方面取得革命性的进展。慢性病的传播和严重性的增加，加上对选择性、非侵入性治疗的需求，产生了对更有效疗法的需求。除了经济和具有长期的化学和物理稳定性外，理想的治疗系统应该是多功能的，提供疾病靶向、成像、诊断和药物输送能力。磁性金核-壳纳米粒子代表了一种可以实现多种治疗目标的系统。学生将通过直接培训、课程开发和STEM外展受到这项工作的影响。该项目由工程局化学、生物、环境和运输部的颗粒和多阶段工艺和热传输工艺项目联合资助。

1337061PI: BothunA versatile process will be created where small lipid bilayer vesicles or liposomes will be used as biocompatible templates for creating magnetic-gold core-shell nanoparticles with varying core and shell morphologies. The core-shell nanoparticles will provide a structure where the magnetic core responds to permanent magnetic or alternating radiofrequency (RF) electromagnetic fields, and the gold shell responds photonically to ultraviolet-visible or near infrared (NIR) light. RF and NIR absorbance will be examined as a function of core-shell structure, including spherical and tubular geometries. By exploiting the ability of the core-shell nanoparticles to convert the absorbed field energy into heat, controlled release from liposome-templated nanoparticles using dual NIR and RF triggers will be examined. This approach represents an original strategy and the project is expected to lead to transformative advances in the way multifunctional nanoparticles are synthesized and the way nanoparticles respond and react to simultaneous NIR and RF fields.Rises in the spread and severity of chronic diseases coupled with the need for selective, non-invasive treatments have created a demand for more effective therapies. In addition to being economical and having long-term chemical and physical stability, the ideal therapeutic system would be multifunctional providing disease targeting, imaging, diagnostic, and drug delivery capabilities. Magnetic-gold core-shell nanoparticles represent such a system where multiple therapeutic objectives can be realized. Students will impacted by this work through direct training, curriculum development, and STEM outreach.This project is jointly funded by Particulate and Multiphase Processes and Thermal Transport Processing Programs in Chemical, Biological, Environmental, and Transport Division in Engineering Directorate.