Multifunctional and Stimuli-Responsive Core-Shell Nanoparticles Based on Liposome Templating

1337061 PI：BothunA将创建一个通用的过程，其中小的脂质双层囊泡或脂质体将被用作生物相容性模板，用于创建具有不同核和壳形态的磁性金核壳纳米颗粒。核-壳纳米颗粒将提供一种结构，其中磁芯响应于永磁或交变射频（RF）电磁场，并且金壳对紫外-可见或近红外（NIR）光进行光子响应。RF和NIR吸光度将作为核壳结构的函数进行检查，包括球形和管状几何形状。通过利用核-壳纳米颗粒将吸收的场能转化为热的能力，将检查使用双NIR和RF触发剂从脂质体模板化的纳米颗粒的受控释放。这种方法代表了一种原创策略，该项目有望在多功能纳米颗粒的合成方式以及纳米颗粒对同时发生的近红外和射频场的响应和反应方式方面带来变革性进展。慢性疾病的传播和严重程度的上升，加上对选择性非侵入性治疗的需求，创造了对更有效治疗的需求。除了经济和具有长期的化学和物理稳定性之外，理想的治疗系统将是多功能的，提供疾病靶向、成像、诊断和药物递送能力。磁性金核壳纳米颗粒代表了这样一个系统，其中可以实现多个治疗目标。学生将通过直接培训，课程开发和STEM外展受到这项工作的影响。该项目由工程理事会化学，生物，环境和运输部门的颗粒和多相过程和热传输处理计划共同资助。

1337061PI: BothunA versatile process will be created where small lipid bilayer vesicles or liposomes will be used as biocompatible templates for creating magnetic-gold core-shell nanoparticles with varying core and shell morphologies. The core-shell nanoparticles will provide a structure where the magnetic core responds to permanent magnetic or alternating radiofrequency (RF) electromagnetic fields, and the gold shell responds photonically to ultraviolet-visible or near infrared (NIR) light. RF and NIR absorbance will be examined as a function of core-shell structure, including spherical and tubular geometries. By exploiting the ability of the core-shell nanoparticles to convert the absorbed field energy into heat, controlled release from liposome-templated nanoparticles using dual NIR and RF triggers will be examined. This approach represents an original strategy and the project is expected to lead to transformative advances in the way multifunctional nanoparticles are synthesized and the way nanoparticles respond and react to simultaneous NIR and RF fields.Rises in the spread and severity of chronic diseases coupled with the need for selective, non-invasive treatments have created a demand for more effective therapies. In addition to being economical and having long-term chemical and physical stability, the ideal therapeutic system would be multifunctional providing disease targeting, imaging, diagnostic, and drug delivery capabilities. Magnetic-gold core-shell nanoparticles represent such a system where multiple therapeutic objectives can be realized. Students will impacted by this work through direct training, curriculum development, and STEM outreach.This project is jointly funded by Particulate and Multiphase Processes and Thermal Transport Processing Programs in Chemical, Biological, Environmental, and Transport Division in Engineering Directorate.