SBIR Phase I: Synthetic pathway in Pichia pastoris for production of 1,2-propanediol from crude glycerol

SBIR 第一阶段：毕赤酵母中从粗甘油生产 1,2-丙二醇的合成途径

• 批准号: 1013619
• 负责人: Wilbur Campbell
• 金额: --
• 依托单位: Nitrate Elimination Company, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1013619&HistoricalAwards=false
• 关键词: SBIR; Phase; Synthetic; pathway; Pichia

This SBIR Phase I project will produce 1,2- propanediol (propylene glycol) from biodiesel byproduct glycerol using a synthetic biology approach in a Pichia pastoris as cell factory. This compound has wide scope in industries from fuel additive to de-icing agent.The broader/commercial impact of the project will be the application of biotechnology to the solution of environmental problems. The market opportunity for the output from this project is broad. In current practice, the transesterification of plant liquids generates crude glycerol as a byproduct and this byproduct could be an additional raw substrate for many value-added compounds and production of 1, 2-propanediol.

该SBIR第一阶段项目将使用合成生物学方法在毕赤酵母细胞工厂中从生物柴油副产物甘油生产1，2-丙二醇（丙二醇）。该化合物在从燃料添加剂到除冰剂的工业中具有广泛的应用范围。该项目的更广泛/商业影响将是应用生物技术解决环境问题。 该项目产出的市场机会广阔。 在目前的实践中，植物液体的酯交换产生粗甘油作为副产物，并且该副产物可以是用于许多增值化合物和1，2-丙二醇生产的额外的原料底物。