Strategically strengthening declarative memories during sleep

在睡眠期间有策略地强化陈述性记忆

• 批准号: 1025697
• 负责人: Ken Paller
• 金额: $ 50万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1025697&HistoricalAwards=false
• 关键词: Strategically; strengthening; declarative; memories; during

The ability to accurately remember information is central to human success. Yet, as new information is added every day, the human brain's expanding storehouse of memories requires continual restructuring. How can the massive influx of new information be used to best advantage? With funding from the National Science Foundation, Ken Paller, Ph.D., of Northwestern University is investigating the intriguing hypothesis that brain events during sleep are instrumental for effective memory storage. Although some memories rapidly fade away, others endure for years, presumably because of a progression of changes in brain networks. It remains unclear how memories are enduringly stored in the human brain, and to what extent sleep might be helpful. This project explores a novel way in which memory storage can be improved. Specific sounds related to information learned previously are presented softly while an individual sleeps. These sounds can in theory prompt memory rehearsal during sleep, leading to an improvement in memory tested a short time after awakening. The procedures thus provide an opportunity to observe a potential benefit of sleep -- memory strengthening that could underlie lasting memory storage. This project explores the procedures whereby these "sleep-sounds" are effective, including (a) determining whether long-lasting memory improvement can be produced by sleep-sounds, (b) comparing learning of spatial locations, of words, and of specific manual actions, and (c) showing which stages of sleep are amenable to this memory strengthening. Experiments also compare the memory strengthening that is possible when participants are awake versus asleep. Electroencephalographic measures of brain activity are included in the project to further elucidate the brain mechanisms of memory improvement during sleep. Although it is widely thought that new information cannot be learned during sleep, information learned before going to sleep can apparently be rehearsed during sleep. This project provides new evidence about how a period of sleep can lead to memory improvement and how that improvement can be focused on specific information.Results obtained through this project provide new leverage on understanding memory storage in general, and memory processing during sleep in particular. This project is expanding knowledge about the special role that sleep can play in the stabilization of memories and in the formation of interconnections among these memories that can be the basis for creative thinking. By advancing understanding of how memories are strengthened during sleep, implications will ultimately arise for promoting optimal educational outcomes in the classroom, enhancing the daily acquisition of new information and skills, and evaluating memory in legal contexts, among other applications. An appreciation of sleep and learning will also aid efforts to emphasize the importance of suitable amounts of sleep for public health.

准确记忆信息的能力是人类成功的核心。然而，随着每天都有新的信息加入，人类大脑不断扩大的记忆库需要不断的重组。如何才能最大限度地利用大量涌入的新信息？在国家科学基金会的资助下，肯·帕勒博士，美国西北大学的一位教授正在研究一个有趣的假设，即睡眠中的大脑活动有助于有效的记忆储存。虽然有些记忆会迅速消失，但有些记忆会持续多年，这可能是因为大脑网络发生了一系列变化。目前还不清楚记忆是如何在人脑中储存的，以及睡眠在多大程度上是有帮助的。这个项目探索了一种可以改善记忆存储的新方法。与先前学习的信息相关的特定声音在个体睡眠时柔和地呈现。理论上，这些声音可以在睡眠期间促进记忆排练，导致醒来后短时间内测试的记忆改善。因此，这些程序提供了一个观察睡眠潜在益处的机会--记忆增强，这可能是持久记忆存储的基础。这个项目探索了这些“睡眠声音”有效的程序，包括（a）确定睡眠声音是否可以产生持久的记忆改善，（B）比较空间位置，单词和特定手动动作的学习，以及（c）显示哪些睡眠阶段适合于这种记忆强化。实验还比较了参与者清醒与睡眠时可能的记忆强化。该项目包括脑活动的脑电图测量，以进一步阐明睡眠期间记忆改善的大脑机制。虽然人们普遍认为在睡眠中无法学习新的信息，但在睡觉前学习的信息显然可以在睡眠中排练。这个项目提供了新的证据，说明睡眠如何改善记忆，以及这种改善如何集中在特定的信息上。通过这个项目获得的结果为理解一般的记忆储存，特别是睡眠期间的记忆处理提供了新的杠杆。该项目正在扩大有关睡眠在稳定记忆和形成这些记忆之间的相互联系方面所发挥的特殊作用的知识，这些记忆可以成为创造性思维的基础。通过进一步了解记忆在睡眠期间是如何加强的，最终将对促进课堂上的最佳教育成果、增强新信息和技能的日常获取以及在法律的背景下评估记忆等应用产生影响。对睡眠和学习的欣赏也将有助于强调适量睡眠对公共健康的重要性。