SPP 1608: Ultrafast and Temporally Precise Information Processing: Normal and Dysfunctional Hearing

SPP 1608：超快和时间精确的信息处理：正常和功能障碍的听力

• 批准号: 198624999
• 金额: --
• 依托单位: Fachgebiet Tierphysiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/198624999?language=en
• 关键词: SPP; 1608; Ultrafast; Temporally; Precise

Ultrafast signalling and an exquisitely high temporal precision down to the microsecond range are the hallmarks of the auditory system that set it apart from virtually any other sensory system. The aim of this Priority Programme is to identify and analyse the mechanisms in the peripheral and central auditory systems, which enable temporally precise information processing. Both normal and dysfunctional hearing will be addressed, linking basic and disease-oriented research. Whereas middle ear-based hearing loss can be treated well, there is no causative treatment for sensorineural hearing loss affecting the cochlea and/or the auditory nerve. Moreover, rehabilitation by hearing aids as well as cochlear and brainstem implants is only partially effective. Although these hearing devices best enable speech comprehension in the quiet, temporal aspects of the auditory signals are not well processed, leading to speech recognition impairment, problems in distinguishing meaningful sounds from background noise, and severe problems in sound localisation. Deficits in temporal processing can also result from structural and functional abnormalities in the central auditory system, such as the various relay stations in the brainstem. The exact causes of such sound-processing impairments are unknown so far. Also, the mechanisms whose dysfunction leads to temporal auditory processing disorders - be it in the cochlea, the auditory nerve or the brain - have not been identified. Therefore, a better understanding of the (patho)-physiology of ultrafast signalling and temporally precise information processing is indispensible if we want to develop effective treatment strategies for hearing disorders. The goal is to obtain a comprehensive knowledge of the mechanisms underlying ultrafast auditory processing with high precision, with the aims of achieving a fundamentally improved understanding of the causes of hearing disorders and tools for better therapeutic treatment. To achieve this goal, our Priority Programme will network renowned and young researchers in physiology, anatomy, human and mouse genetics, computational neuroscience, and behavioural studies, who, so far, have not participated in such a joint initiative.

超快的信号传递和精确到微秒级的时间精确度是听觉系统的标志，使其与几乎任何其他感觉系统区分开来。该优先方案的目的是确定和分析外周和中枢听觉系统中的机制，这些机制使信息处理在时间上精确。正常和功能失调的听力将得到解决，连接基础和疾病为导向的研究。虽然中耳听力损失可以得到很好的治疗，但对于影响耳蜗和/或听神经的感音神经性听力损失没有病因治疗。此外，通过助听器以及耳蜗和脑干植入物进行的康复仅部分有效。虽然这些听力设备最好地使语音理解在安静，听觉信号的时间方面没有得到很好的处理，导致语音识别障碍，在区分有意义的声音从背景噪声的问题，以及在声音定位的严重问题。时间处理的缺陷也可能是由中枢听觉系统的结构和功能异常引起的，例如脑干中的各种中继站。到目前为止，这种声音处理障碍的确切原因还不清楚。此外，功能障碍导致暂时性听觉处理障碍的机制----无论是在耳蜗、听觉神经还是大脑----尚未确定。因此，更好地了解（病理）生理学的超快信号和时间精确的信息处理是必不可少的，如果我们想开发有效的治疗策略，听力障碍。目标是获得高精度超快听觉处理机制的全面知识，目的是从根本上提高对听力障碍原因的理解，并提供更好的治疗工具。为了实现这一目标，我们的优先计划将在生理学，解剖学，人类和小鼠遗传学，计算神经科学和行为研究方面建立知名和年轻的研究人员网络，这些研究人员迄今为止尚未参加过这样的联合倡议。

项目成果

ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+ Clearance

• DOI: 10.1523/jneurosci.4990-13.2014
• 发表时间: 2014-05
• 期刊: The Journal of Neuroscience
• 作者: Simon Weiler;Stefanie Krinner;A. Wong;T. Moser;T. Pangršič

RESPONSE PROPERTIES OF LOCAL FIELD POTENTIALS AND MULTIUNIT ACTIVITY IN THE MOUSE VISUAL CORTEX

• DOI: 10.1016/j.neuroscience.2013.08.065
• 发表时间: 2013-12-19
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Land, R.;Engler, G.;Engel, A. K.
• 通讯作者: Engel, A. K.

The effect of fluctuating maskers on speech understanding of high-performing cochlear implant users

• DOI: 10.3109/14992027.2015.1128124
• 发表时间: 2016-05-03
• 期刊: INTERNATIONAL JOURNAL OF AUDIOLOGY
• 影响因子: 2.7
• 作者: Zirn, Stefan;Polterauer, Daniel;Hemmert, Werner
• 通讯作者: Hemmert, Werner

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.

人类皮质中的谷氨酰胺环化酶：与 (pGlu)-淀粉样蛋白-β 负荷和阿尔茨海默病认知能力下降的相关性

• DOI: 10.3233/jad-131535
• 发表时间: 2014
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Morawski M;Schilling S;Kreuzberger M;Waniek A;Jäger C;Koch B;Cynis H;Kehlen A;Arendt T;Hartlage- Rübsamen M;Demuth HU;Roßner S
• 通讯作者: Roßner S

6.1 Physiologie und Pathophysiologie: visuelles und akustisches System

6 1 生理学和病理生理学：视觉和听觉系统

• DOI: 10.1055/b-0034-44291
• 发表时间: 2013
• 作者: Reichenbach A;Rübsamen R
• 通讯作者: Rübsamen R