UBM Group - An Integrative Biomathematical Learning and Empowerment Network for Diversity (iBLEND)

UBM 集团 - 多元化生物数学综合学习和赋权网络 (iBLEND)

• 批准号: 1029426
• 负责人: Gregory Goins
• 金额: $ 24万
• 依托单位: North Carolina Agricultural & Technical State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1029426&HistoricalAwards=false
• 关键词: UBM; Group; Integrative; Biomathematical; Learning

This project builds on a previous UBM Group project (0634598). Its overarching goal is to encourage, enable, and support students to do research at the interface of mathematics and biology on such diverse topics as functional site analysis of protein superfamilies, quantitative determination of phytochemical components and dynamics, flavanoid signaling and pathway modeling in Arabadopsis, mechanisms of microbial pathogenesis, and dynamics of cancer progression. It takes advantage of newly established genomics, proteomics and computational core laboratories and, through its support of interdisciplinary teams of mathematics and biology students and faculty, is helping to catalyze North Carolina A&T State University's (NCATSU) initiative to increase interdisciplinary (Math/bio) approaches in their research and curricular efforts. Intellectual Merit: The project is being coordinated by the Mathematics, Biology, and General Education Departments and is helping to expand the intellectual foundation of both research and education at NCATSU. The cross-cutting applied nature of mathematical modeling and systems biology facilitates students from different disciplines working together and gaining a broader view than single-investigator projects. The modeling intellectual focus and tools span the range from prediction to identification of mechanistic structures. The research themes are specifically structured to complement the individual strengths and circumstances of each research mentor. Math-biology student teams work in tandem on specific projects in order to gain experience with mathematical models of biological applications. They are gaining a deeper understanding of the governing processes at the molecular, cellular, and organismal level through mathematical analysis of the overall dynamical system models and various numerical methods and simulations. Broader Impact: The project is broadening diversity in biomathematics-related professions; providing mutual reinforcement between research and classroom activity; and providing a collaborative network for learning and teaching at the biomathematics interface. It is serving as a model for building curricular frameworks, coupled with meaningful undergraduate collaborative research experiences that attract and retain minority students on a competitive trajectory for biomathematical graduate study. The Mathematics and Biology Departments together are seeking to expand its success by disseminating information about its outcomes to a broad spectrum of other institutions.

该项目建立在以前的UBM组项目（0634598）上。 它的总体目标是鼓励，启用和支持学生在数学和生物学的界面上进行研究，以诸如蛋白质超家族的功能站点分析，对植物化学组件的定量确定，动态，类黄酮素的信号和阿拉伯语模型，在阿拉伯语中建模，机制，以及微生物病理学的机制，以及动态癌症的机制。 它利用了新成立的基因组学，蛋白质组学和计算核心实验室，并通过支持数学和生物学学生和教职员工的跨学科团队，正在帮助催化北卡罗来纳州A＆T州立大学（NCATSU）的倡议，以增加研究和研究的跨学科（数学BIO）。 知识分子的优点：该项目由数学，生物学和普通教育部门协调，并正在帮助扩大NCATSU研究和教育的知识基础。数学建模和系统生物学的跨剪切应用性质促进了来自不同学科的学生，并获得比单一评估项目更广泛的观点。建模智力重点和工具涵盖了从预测到机械结构识别的范围。研究主题是专门的，以补充每个研究导师的个人优势和情况。数学生物学学生团队在特定项目方面统一工作，以获得生物应用数学模型的经验。他们通过数学分析整体动力学系统模型以及各种数值方法和仿真，对分子，细胞和生物层的治理过程有了更深入的了解。 更广泛的影响：该项目正在扩大与生物学相关的职业的多样性；在研究和课堂活动之间提供相互加强；并在生物学接口上提供用于学习和教学的协作网络。 它是建立课程框架的模型，再加上有意义的本科协作研究经验，这些研究经验吸引并留住了少数族裔学生，以竞争性轨迹进行生物心理研究生研究。 数学和生物学部门共同寻求通过将有关结果的信息传播到其他机构来扩大其成功。