UBM Group - An Integrative Biomathematical Learning and Empowerment Network for Diversity (iBLEND)

UBM 集团 - 多元化生物数学综合学习和赋权网络 (iBLEND)

• 批准号: 1029426
• 负责人: Gregory Goins
• 金额: $ 24万
• 依托单位: North Carolina Agricultural & Technical State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1029426&HistoricalAwards=false
• 关键词: UBM; Group; Integrative; Biomathematical; Learning

This project builds on a previous UBM Group project (0634598). Its overarching goal is to encourage, enable, and support students to do research at the interface of mathematics and biology on such diverse topics as functional site analysis of protein superfamilies, quantitative determination of phytochemical components and dynamics, flavanoid signaling and pathway modeling in Arabadopsis, mechanisms of microbial pathogenesis, and dynamics of cancer progression. It takes advantage of newly established genomics, proteomics and computational core laboratories and, through its support of interdisciplinary teams of mathematics and biology students and faculty, is helping to catalyze North Carolina A&T State University's (NCATSU) initiative to increase interdisciplinary (Math/bio) approaches in their research and curricular efforts. Intellectual Merit: The project is being coordinated by the Mathematics, Biology, and General Education Departments and is helping to expand the intellectual foundation of both research and education at NCATSU. The cross-cutting applied nature of mathematical modeling and systems biology facilitates students from different disciplines working together and gaining a broader view than single-investigator projects. The modeling intellectual focus and tools span the range from prediction to identification of mechanistic structures. The research themes are specifically structured to complement the individual strengths and circumstances of each research mentor. Math-biology student teams work in tandem on specific projects in order to gain experience with mathematical models of biological applications. They are gaining a deeper understanding of the governing processes at the molecular, cellular, and organismal level through mathematical analysis of the overall dynamical system models and various numerical methods and simulations. Broader Impact: The project is broadening diversity in biomathematics-related professions; providing mutual reinforcement between research and classroom activity; and providing a collaborative network for learning and teaching at the biomathematics interface. It is serving as a model for building curricular frameworks, coupled with meaningful undergraduate collaborative research experiences that attract and retain minority students on a competitive trajectory for biomathematical graduate study. The Mathematics and Biology Departments together are seeking to expand its success by disseminating information about its outcomes to a broad spectrum of other institutions.

该项目建立在以前的UBM集团项目（0634598）的基础上。 它的总体目标是鼓励，使和支持学生在数学和生物学的接口上进行研究，这些不同的主题包括蛋白质超家族的功能位点分析，植物化学成分和动力学的定量测定，类黄酮信号传导和途径建模，微生物发病机制和癌症进展的动力学。 它利用新建立的基因组学，蛋白质组学和计算核心实验室，并通过其数学和生物学的学生和教师的跨学科团队的支持，正在帮助催化北卡罗来纳州AT州立大学（NCATSU）的倡议，以增加跨学科（数学/生物）的方法在他们的研究和课程的努力。 智力优势：该项目由数学，生物和普通教育部门协调，并有助于扩大NCATSU研究和教育的知识基础。数学建模和系统生物学的交叉应用性质有助于来自不同学科的学生一起工作，并获得比单一研究者项目更广泛的视野。建模的智能焦点和工具涵盖了从预测到机械结构识别的范围。研究主题是专门为补充每个研究导师的个人优势和情况而设计的。数学-生物学学生团队在特定项目上协同工作，以获得生物应用数学模型的经验。他们通过对整个动力系统模型和各种数值方法和模拟的数学分析，对分子，细胞和生物体水平的管理过程有了更深入的了解。 更广泛的影响：该项目正在扩大生物数学相关专业的多样性;提供研究和课堂活动之间的相互加强;并在生物数学界面提供学习和教学的协作网络。 它是作为一个模型，建立课程框架，再加上有意义的本科合作研究经验，吸引和保留少数民族学生在生物数学研究生学习的竞争轨迹。 数学和生物系一起寻求通过传播有关其成果的信息，以扩大其成功的其他机构的广泛范围。