Engineering Rapid and Ultrasensitive Microsystem with Hybrid Nanomaterials

使用混合纳米材料设计快速、超灵敏的微系统

• 批准号: 1030289
• 负责人: Susan Zhou
• 金额: $ 20万
• 依托单位: Worcester Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1030289&HistoricalAwards=false
• 关键词: Engineering; Rapid; Ultrasensitive; Microsystem; Hybrid

The goal of this project is to engineer a rapid and ultrasensitive microsystem that has the function of efficient preconcentration, and rapid as well as ultrasensitive detection using magnetic nanoparticles. This project utilizes an interdisciplinary approach to study the nanoparticle-enhanced preconcentration and detection, and its integration to the microfluidic device. Microreactor concept for the mixing unit will be used to predict and characterize the seperation efficiency, considering the magnetically active mixing and transport in the preconcentration unit. Magnetic nanoparticle will be used as label to amplify detection signal for miniaturizable Surface Plasmon Resonance (SPR) detection.The integrated sensing microsystem has the prospect of producing low-cost, rapid, and hand-held devices for the practice of diagnostic medicine, the identification of biological weapons, the control of food safety and environmental pollutions, and basic life sciences research. The layered architecture of integrated research and mentoring for a continuum of students from middle school to graduate students will advance awareness of bionanotechnology to middle school teachers/students through Research Experience for Teachers (RET) program. It will also provide opportunities to recruit and retain underrepresented students, with a focus on female students.

该项目的目标是设计一种快速和超灵敏的微系统，具有高效预浓缩的功能，并使用磁性纳米颗粒进行快速和超灵敏的检测。该项目采用跨学科的方法来研究纳米颗粒增强的预浓缩和检测，以及它与微流控设备的集成。混合单元的微反应器概念将被用来预测和表征分离效率，考虑预选单元中的磁活性混合和输运。利用磁性纳米粒子作为标记放大检测信号，实现表面等离子体共振(SPR)的小型化检测，集成传感微系统有望在诊断医学、生物武器识别、食品安全和环境污染控制、基础生命科学研究等领域制造低成本、快速的手持设备。为从中学到研究生的学生提供综合研究和指导的分层架构将通过教师研究体验(RET)计划提高中学教师/学生对生物科技的认识。它还将提供招收和留住代表性不足学生的机会，重点是女学生。