MRI: Development of a High-Resolution Positron Imaging System Dedicated to Plant Research

MRI：开发专用于植物研究的高分辨率正电子成像系统

• 批准号: 1040498
• 负责人: Yuan-Chuan Tai
• 金额: $ 104.32万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1040498&HistoricalAwards=false
• 关键词: MRI; Development; Resolution; Positron; Imaging

This Major Research Instrumentation award funds the development of a novel positron emission tomography (PET) system for plant imaging using an innovative virtual pinhole detector geometry. The new PET system will provide sub-millimeter resolution PET imaging capability. The system will be fully integrated into a plant growth chamber that is fitted with lighting, temperature, humidity and CO2 control so that the plant can be studied in a well controlled environment (including elevated CO2 concentrations).Radioactive gas delivery system and labeling apparatus will also be developed and integrated into the growth chamber to enable plant imaging using PET tracers under a controlled environment. The system will enable several in planta molecular imaging research projects that may (1) understand how crop yields will be affected at elevated atmospheric CO2 level; (2) improve the yield and extend the shelf life of cassava to aid food shortage problem in Africa; (3) accelerate the selection of genetically modified crops by accurately predicting the yield without full scale field experiment; (4) better understand the effect of plant hormone for growth control and defending diseases. The results of the research and development efforts will be broadly disseminated through abstracts and peer reviewed publications, as well as by active participation of students and faculty at professional meetings.

该重大研究仪器奖资助开发一种新型正电子发射断层扫描 (PET) 系统，该系统使用创新的虚拟针孔探测器几何结构进行植物成像。新的 PET 系统将提供亚毫米分辨率的 PET 成像能力。 该系统将完全集成到配有照明、温度、湿度和二氧化碳控制的植物生长室中，以便可以在良好控制的环境（包括升高的二氧化碳浓度）中研究植物。还将开发放射性气体输送系统和标记装置并将其集成到生长室中，以便在受控环境下使用 PET 示踪剂进行植物成像。 该系统将启用多个植物分子成像研究项目，这些项目可能（1）了解大气二氧化碳水平升高时农作物产量将如何受到影响； （2）提高木薯产量并延长保质期，以缓解非洲粮食短缺问题； （3）无需进行大规模田间试验即可准确预测产量，加速转基因作物的选择； (4)更好地了解植物激素的生长控制和防病作用。 研究和开发工作的成果将通过摘要和同行评审出版物以及学生和教师积极参与专业会议来广泛传播。