The influence of antigen distribution on quality and repertoire of CD8+ T cell responses

抗原分布对 CD8 T 细胞反应质量和库的影响

• 批准号: 200114013
• 负责人: Professor Dr. Thomas Brocker
• 金额: --
• 依托单位: Forschungsbereich Immunologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200114013?language=en
• 关键词: influence; antigen; distribution; quality; repertoire

CD8+ T lymphocytes recognize specific peptide/MHC class I complexes in the context of costimuli on antigen-presenting dendritic cells (DCs). Thereafter they differentiate into effector and memory cytotoxic T lymphocytes (CTL) able to confer protection against pathogen infection. Due to their central role in T cell “priming”, DCs are key candidates for antibody targeting and are used as cellular vaccines for clinical purposes. Using transgenic mice where only DCs can prime CD8+ T cells, we will analyse the quantitative and qualitative influence of selective DC-priming on CD8+ T cell effector and memory responses.

CD8+ T淋巴细胞在抗原呈递树突状细胞（dc）的共刺激下识别特异性肽/MHC I类复合物。此后，它们分化为效应细胞毒性T淋巴细胞和记忆细胞毒性T淋巴细胞（CTL），能够保护细胞免受病原体感染。由于它们在T细胞“启动”中的核心作用，dc是抗体靶向的关键候选物，并用作临床目的的细胞疫苗。我们将利用只有dc才能启动CD8+ T细胞的转基因小鼠，定量和定性地分析选择性dc启动对CD8+ T细胞效应和记忆反应的影响。

项目成果

CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells

• DOI: 10.1073/pnas.1423356112
• 发表时间: 2015-04-28
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Bernhard, Caroline A.;Ried, Christine;Brocker, Thomas
• 通讯作者: Brocker, Thomas