Transient Intermediates in Proton and Electron Transfer

美国国家科学基金会化学部的化学结构、动力学和机理计划支持华盛顿大学的Frank Turecek教授对生物大分子中的电子俘获解离和电子转移解离反应进行质谱学研究。这项研究的目标是为多肽和蛋白质提供新的鉴定方法，包括与非共价相互作用(三级结构)和翻译后修饰有关的结构特征。这项研究的广泛影响基于图雷切克教授独特的能力，即利用他对有机离子反应机理和计算化学的知识来评估这些活性中间体中的能量分布，以及他的团队设计和制造新型质谱仪的能力。他的研究小组在广泛的学科领域获得了专业知识。他们对多肽结构的研究结果影响了生物化学和制药工业领域。

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Frank Turecek of the University of Washington, for mass spectrometry studies of electron capture dissociation and electron transfer dissociation reactions in biomacromolecules. The goal of this research is to provide new identification methods for peptides and proteins, including structural features connected to non-covalent interactions (tertiary structure) and post-translational modifications.Broader impacts of the research are based on Professor Turecek's unique abilities to use his knowledge of organic ion reaction mechanisms and computational chemistry to assess energy distribution in these reactive intermediates, and his group's ability to design and build novel instrumentation for mass spectrometry. His research group gains expertise across a broad range of disciplines. The results of their investigations on peptide structure impact the fields of biochemistry and the pharmaceutical industry.