ROS as Mediators of Rapid Long-Distance Self-Propagating Signals

ROS作为快速长距离自传播信号的中介

• 批准号: 1063287
• 负责人: Ron Mittler
• 金额: $ 57.5万
• 依托单位: University of North Texas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-31 至 2015-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1063287&HistoricalAwards=false
• 关键词: ROS; Mediators; Rapid; Long; Distance

Plants are the principle solar energy converter sustaining life on Earth. To optimize their carbon dioxide consumption and bio-energy production, plants must rapidly acclimate to changes in their environment, as well as respond to a diverse array of biological challenges. Being sessile organisms, plants evolved sophisticated mechanisms to cope with biotic and abiotic challenges in their environment. These can be activated in local tissues that initially interact with the threat, as well as in systemic tissues that were not yet challenged. The activation of defense or acclimation mechanisms in systemic non-challenged tissues is often termed systemic acquired resistance, or systemic acquired acclimation, and serves an important role in preventing further infection or damage to the entire plant during stress. Fundamental mechanisms underlying rapid systemic signaling in response to different environmental stresses in plants are however largely unknown. The long-term goal of this project is to determine the mechanism and mode of regulation of rapid systemic signaling in plants. Dissecting the rapid systemic signaling pathway of plants will identify key regulators that will be used to enhance the tolerance of different crops and plants to global climatic changes, potentially preventing yield losses estimated at 30-40 billions of dollars annually in the US. This project will involve educational outreach for K-12 and multidisciplinary training to graduate and undergraduate trainees. Undergraduate students will be trained in different aspects of signal transduction, genetics and bioinformatics analysis. A summer outreach workshop will teach high school students about molecular biology, signal transduction, the environment, and modern agriculture. This laboratory-based internship program will provide self-confidence building experiences and expose the students to laboratories and scientists. Both undergraduate and K-12 outreach and training activities will target the under privileged and underrepresented in science.

植物是维持地球寿命的主要太阳能转化器。为了优化其二氧化碳消耗和生物能源生产，植物必须迅速适应环境的变化，并应对各种各样的生物学挑战。作为无柄生物，植物发展出了复杂的机制，以应对其环境中的生物和非生物挑战。这些可以在最初与威胁相互作用的本地组织以及尚未受到挑战的全身组织中激活。全身性非挑战组织中防御或适应机制的激活通常被称为全身性获得的抵抗力或全身性获得的适应，并且在防止压力期间对整个植物的进一步感染或损害中发挥着重要作用。然而，响应植物中不同环境应力的快速全身信号的基本机制在很大程度上尚不清楚。该项目的长期目标是确定植物中快速全身信号的调节机制和模式。解剖植物的快速全身信号通路将确定关键调节剂，这些调节剂将用于增强对全球气候变化的不同农作物和植物的耐受性，从而有可能预防美国每年估计为300亿美元的产量损失。该项目将涉及K-12和多学科培训的教育宣传，以毕业和本科学员。本科生将接受信号转导，遗传学和生物信息学分析的不同方面的培训。夏季外展研讨会将教高中生分子生物学，信号转导，环境和现代农业。这项基于实验室的实习计划将提供自信的建设经验，并使学生接触实验室和科学家。本科生和K-12外展和培训活动都将针对科学的特权和人数不足。