Integrating developmental morphogenetic theory and dental biodistance practices

整合发育形态发生理论和牙科生物距离实践

• 批准号: 1063942
• 负责人: Christopher Stojanowski
• 金额: $ 25万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1063942&HistoricalAwards=false
• 关键词: Integrating; developmental; morphogenetic; theory; dental

Differences in the size and shape of teeth are used in a variety of ways, from reconstructing evolutionary relationships between species to identifying individuals in modern forensics cases. As such, it is critical that we understand how tooth size and shape are inherited by studying the dentition in family trees. The Albert Dahlberg collection of dental casts is one of the largest in the world and consists of 7500 dentitions representing 3000 individuals. Most individuals are situated in known family trees thus allowing the researchers to explore the genetics of how dental characteristics are passed between generations. Previous work on the collection has contributed to our understanding of dental genetics, development, and evolution; however, the full potential of this archive has never been realized. Recent advances in developmental biology, genetic statistical tools and software, and 3D scanning technology now permit an exploration of tooth genetics in ways not previously possible, while scanning will also preserve this fragile resource for use by future generations. The project will record a comprehensive set of metric and nonmetric data from the collection. Using these data, project staff will generate heritability estimates for a large number of dental features using large sample sizes and complex statistical models. The project will also explore how dental features infer evolutionary relationships and how they identify closely related individuals based on their dental similarities. The dissemination of highly accurate digital models of the casts will provide researchers with the needed data to test a number of assumptions about how tooth size and shape are inherited and modified by evolutionary mechanisms. The project will benefit anthropology, developmental biology, paleontology, clinical dentistry and forensic dentistry. The larger significance is making this collection widely available to remote researchers, who will be able to mine and analyze the data in currently unknown ways for generations to come.

牙齿大小和形状的差异被用于各种各样的方式，从重建物种之间的进化关系到在现代法医案件中识别个体。因此，我们必须通过研究家谱中的牙列来了解牙齿大小和形状是如何遗传的。Albert Dahlberg的牙模收藏是世界上最大的牙模收藏之一，包括代表3000人的7500个牙系。大多数个体都位于已知的家谱中，从而使研究人员能够探索牙齿特征如何在几代人之间传递的遗传学。以前的工作对收集有助于我们的牙齿遗传学，发展和进化的理解;然而，这个档案的全部潜力从来没有实现。发育生物学、遗传统计工具和软件以及3D扫描技术的最新进展现在允许以以前不可能的方式探索牙齿遗传学，同时扫描也将保护这一脆弱的资源供后代使用。该项目将记录来自收集的一组全面的度量和非度量数据。 利用这些数据，项目工作人员将使用大样本量和复杂的统计模型为大量牙齿特征生成遗传率估计。该项目还将探讨牙齿特征如何推断进化关系，以及它们如何根据牙齿相似性识别密切相关的个体。高度精确的数字模型的传播将为研究人员提供所需的数据，以测试一些关于牙齿大小和形状如何通过进化机制遗传和修改的假设。该项目将使人类学、发育生物学、古生物学、临床牙科学和法医牙科学受益。 更大的意义是使这些收集广泛提供给远程研究人员，他们将能够以目前未知的方式为后代挖掘和分析数据。