Fourth International Workshop on Iron and Copper Homeostasis, Pucon, Chile, November 28 - December 3, 2011

第四届铁铜稳态国际研讨会，智利普孔，2011 年 11 月 28 日至 12 月 3 日

• 批准号: 1132351
• 负责人: Michael Garrick
• 金额: $ 1.82万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1132351&HistoricalAwards=false
• 关键词: Fourth; International; Workshop; Iron; Copper

1132351, GarrickThe Fourth International Workshop on Iron and Copper Homeostasis (4IWICH) will be held in Pucón, Chile 28 November - 3 December. As "Fourth" implies, it is the latest in a highly successful series, all held in Chile. The workshop brings together researchers who study iron or copper metabolism or both. Bringing selected members of the first two communities together helps to increase membership in the community that appreciates, understands and actively investigates the overlap between these areas of research. This overlap occurs in multiple ways, some first announced / explored at an IWICH. For examples, presentations and discussions have covered how divalent metal transporter (DMT1, aka SLC11A2, Nramp2, DCT1) transports both metals and considered whether ferrous or ferric (answer ferrous) ions are the substrate or similarly whether cuprous or cupric (answer still debated) ions are transported. Also 3IWICH was where a young American investigator first announced that Menkes Copper Atpase (Atp7a) transcript was elevated in iron deficient rats? intestinal cells establishing a new link between the two metals. Participation of Cu in the activity of ceruloplasmin and hephaestin (multi-copper ferroxidases) also serves as a topic of presentations and discussions at IWICHs. Increasingly roles of the two metals in neurodegenerative disorders are features of the workshop while other links novel and known have been topics at each of the first three IWICHs as well as well as at TEMA (Trace Elements for Man and Animals) 13, an international meeting that intervened after the 3rd workshop and essentially served to postpone the need for the 4th workshop. The international workshops clearly demonstrate the intellectual merit of having such assemblies as does the publication of two special issues of journals (BioMetals and Biological Research) covering the proceedings. Multiple international collaborations have also developed from the formal and informal interactions. Attending one of these conferences has been an important stimulus that attracted multiple young investigators particularly from Chile but also from Asia, Australia, Brazil, Canada, Europe and the USA into research in iron and copper homeostasis. Like 2 of the meetings before it, the 4th workshop will be held at the Gran Hotel in Pucón, Chile, a facility that has full provisions for disabled guests. The host country also has a strong motive for research into copper toxicity because the Andes, the geological backbone of Chile, not only provide a strong economic basis for Chile by being a great source of copper, but also lead to contamination of nearly all fresh water sources with substantial levels of copper. Chile needs to know the long term effects of these exposures. Given that this workshop has already established itself to fit descriptives like strong intellectual impact, promoting international collaborations and having a broad impact on basic research, medical research and environmental studies, one may wonder why there is a need for NSF support. The answer is that the workshop will independently attract from the USA some senior investigators who will use their own research grants or other resources to support their coming, but younger investigators must have travel support in order to attend. The First and Second IWICHs had adequate support from various US grant agencies, but US support declined for the next meeting. The organizers focused their limited resources on bringing some young American scientists to Chile and propose now that the NSF help in this critical function of keeping the newer investigators involved in (and one hopes helping to lead) this field. Particular attention also needs to be paid to how it fits with Biomedical Engineering. Issues like the potential effects of high levels of Cu in the water supply, the meeting?s continuing focus on the roles of Fe, Cu and Mn in neurodegeneration are among the answers. Prevention and treatment through interventions involving metal ions as well as their roles in mitochondria, the suppliers of most cellular energy for cellular movements and function, as critical loci for steps in iron and copper metabolism that are only recently yielding to the new molecular and genomic approaches place 4IWICH on target for bridging basic, medical and environmental sciences as applied to metal ion homeostasis and thus as fitting BME?s themes of neural engineering and cellular biomechanics.

1132351，Garrickthe第四届Iron和Copper体内平衡的国际研讨会（4iwich）将于11月28日至12月3日在智利的Pucón举行。正如“第四”所暗示的那样，这是一个非常成功的系列中的最新系列，全部在智利举行。研讨会汇集了研究铁或铜代谢或两者兼而有之的研究人员。将前两个社区的选定成员聚集在一起有助于增加社区的成员资格，以了解，理解和积极研究这些研究领域之间的重叠。这种重叠以多种方式发生，有些人首先在iwich宣布 /探索。例如，演示和讨论涵盖了二价金属转运蛋白（DMT1，又名SLC11A2，NRAMP2，DCT1）如何运输金属，并考虑是否是底物还是类似的底物或类似的基质（答案）是铜矿或类似的库层（答案仍在辩论）（答案仍然是辩论）。还有3iwich是一名年轻的美国调查员首次宣布Menkes Copper ATPase（ATP7A）的转录本在铁不足的大鼠中升高了吗？肠细胞在两种金属之间建立新的联系。 CU参与Ceruroplasmin和Hephaestin（多型铁氧化酶）的活性也是IWICHS演讲和讨论的主题。两种金属在神经退行性疾病中的越来越多的作用是研讨会的特征，而其他链接和已知的链接是前三个IWICH的每个链接，以及在Tema（人类和动物的痕迹元素）13中的主题，这是一次国际会议，这是一次在第三次研讨会之后进行的，本质上是为了延续了4th Workshop。国际研讨会清楚地表明了拥有涵盖诉讼程序的两个特殊期刊（生物态和生物学研究）的大会的智力优点。从正式和非正式的互动中也发展了多次国际合作。参加其中一场会议一直是一个重要的刺激，吸引了多名年轻调查员，尤其是来自智利，但也吸引了亚洲，澳大利亚，巴西，加拿大，欧洲和美国的铁和铜稳态研究。像之前的两次会议一样，第四次研讨会将在智利的普坎的格兰酒店举行，该设施为残疾人提供了全面的准备。东道国也有强大的研究铜毒性的动机，因为智利的地质骨架安第斯山脉不仅通过成为铜的重要来源为智利提供了强大的经济基础，而且还会导致几乎所有淡水源具有大量铜的淡水来源。智利需要了解这些暴露的长期影响。鉴于该研讨会已经建立了自己，以适应诸如强烈的智力影响，促进国际合作以及对基础研究，医学研究和环境研究产生广泛影响的描述，因此可能会想知道为什么需要NSF支持。答案是，研讨会将独立吸引美国一些高级调查人员，他们将使用自己的研究补助金或其他资源来支持他们的到来，但是年轻的调查人员必须获得旅行支持才能参加。第一和第二的iwichs得到了美国各种赠款机构的足够支持，但美国的支持下降了。现在，组织者将有限的资源集中在将一些年轻的美国科学家带到智利和提议上，因为NSF有助于使新调查人员参与（一个人希望帮助领导）这一领域的关键功能。还需要特别关注它与生物医学工程的适合。诸如CU高水平在供水中的潜在影响之类的问题，会议继续关注FE，CU和MN在神经变性中的作用。通过涉及金属离子的干预措施以及其在线粒体中的作用，最细胞运动和功能的供应商，作为铁和铜代谢步骤的关键部位，这些供应和铜代谢的措施是最近屈服于新的分子和基因组方法，以使基础，医学和环境构造的目标均屈服于新的分子和基因组方法，从而使基本和基因组方法屈服于国内的基本和环境，从而，预防和治疗的预防和治疗。神经工程和细胞生物力学。