Making the Arabidopsis Biological Resource Center Business Model Possible

让拟南芥生物资源中心商业模式成为可能

• 批准号: 1143813
• 负责人: Erich Grotewold
• 金额: $ 57.36万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1143813&HistoricalAwards=false
• 关键词: Making; Arabidopsis; Biological; Resource; Center

Intellectual MeritThe Arabidopsis Biological Resource Center (ABRC) was established in 1991 and supported since by NSF through five-year grants. The ABRC collects, preserves, reproduces and distributes diverse seed and DNA stocks of Arabidopsis thaliana and related species. Information and ordering services for the distributed resources are maintained by The Arabidopsis Information Resource (TAIR; http://arabidopsis.org/). The ABRC serves a dynamic community of plant researchers with a common goal to understand the basic processes of flowering plants, as well as to apply this understanding to further crop improvement. The activity of the Center is essential towards full-filling the community goal of having multiple mutant alleles for every one of the Arabidopsis ~27,000 genes. Approximately 10,000 registered users in TAIR utilize the Center by ordering close to 100,000 stocks annually from a collection of approximately 1,000,000 stocks, equally distributed between seeds and DNA. The impact of the ABRC is represented by a significant contribution to hundreds of articles by the Arabidopsis community in high-impact journals each year. Stock donation and demand continues to grow and is likely to remain high for the foreseeable future. Here, the ABRC requests funds to upgrade and increase the capacity and efficiency of the DNA and seed-handling operations. Specifically, funds are requested for a cold dry room with a specialized rack system for short and long-term seed storage, for a specialized -20 C freezer for very long-term seed storage, a robotic system for increased output in DNA stock operations, and a soil handler to increase planting reproducibility and efficiency. These equipment pieces are central to the realization of a Business Model in which ABRC becomes significantly more independent from NSF support in its operations.Broader ImpactsRealizing the strategic position of the ABRC in the Arabidopsis and plant community, the Center started a pilot program to harness the know-how and stocks at the ABRC to enhance the awareness and visibility of plants in K-12. Towards this objective, ABRC personnel developed a three-module research project entitled "Greening the Classroom: Arabidopsis thaliana as a tool to teach plant genetics", the relationship of plants with the environment, and plant development for high-school students". This plan is currently being implemented in high-schools in the Columbus City School district, and will be expanded to a number of other schools in Ohio. This effort is supported by the Curriculum Quality Control Council of Columbus City Schools (http://www.columbus.k12.oh.us), which included the "Greening the Classroom" initiative in the official curriculum of CCS. In addition, the ABRC participated in the organization of the second Plant Functional Genomics Workshop (http://www.biosci.ohiostate.edu/workshop/). This workshop offered a hands-on practical experience combined with lectures by leaders in the field to ~20 participants (high-school teachers, undergrads, Ph.D. students, postdocs and junior faculty members) from all over the world. These educational initiatives are significantly complementing the sustained and highly-valued community service mission of the ABRC, thus increasing the appreciation for Arabidopsis and plants in general in our younger generations.Co-funded by the Divisions of Molecular and Cellular Biosciences, Integrative Organismal Systems, and Biological Infrastructure.

智力优势拟南芥生物资源中心 (ABRC) 成立于 1991 年，自此得到 NSF 为期五年的资助。 ABRC 收集、保存、繁殖和分发拟南芥及相关物种的多种种子和 DNA 储备。分布式资源的信息和订购服务由拟南芥信息资源（TAIR；http://arabidopsis.org/）维护。 ABRC 服务于一个充满活力的植物研究人员社区，其共同目标是了解开花植物的基本过程，并将这种理解应用于进一步的作物改良。该中心的活动对于实现拟南芥约 27,000 个基因中的每一个都具有多个突变等位基因的社区目标至关重要。 TAIR 的大约 10,000 名注册用户利用该中心，每年从大约 1,000,000 种库存中订购近 100,000 种库存，在种子和 DNA 之间平均分配。 ABRC 的影响力体现在拟南芥界每年在高影响力期刊上发表的数百篇文章中做出的重大贡献。股票捐赠和需求持续增长，并且在可预见的未来可能保持在较高水平。在此，ABRC 请求资金来升级和提高 DNA 和种子处理业务的能力和效率。具体来说，需要资金用于建造一个带有专门机架系统的冷干燥室，用于短期和长期种子储存，用于长期种子储存的专门-20°C冷冻机，用于增加DNA储存操作产量的机器人系统，以及用于提高种植重复性和效率的土壤处理机。这些设备对于实现商业模式至关重要，在这种商业模式中，ABRC 在其运营中变得更加独立于 NSF 支持。更广泛的影响 认识到 ABRC 在拟南芥和植物界的战略地位，该中心启动了一项试点计划，利用 ABRC 的专业知识和库存来提高 K-12 植物的知名度和知名度。为了实现这一目标，ABRC 人员开发了一个由三个模块组成的研究项目，题为“绿化教室：拟南芥作为植物遗传学、植物与环境的关系以及高中生植物发育的教学工具”。该计划目前正在哥伦布市学区的高中实施，并将扩大到俄亥俄州的许多其他学校。这项工作得到了美国俄亥俄州课程质量控制委员会的支持。 哥伦布城市学校 (http://www.columbus.k12.oh.us)，其中将“绿色教室”倡议纳入 CCS 的官方课程。此外，ABRC还参与组织了第二届植物功能基因组学研讨会（http://www.biosci.ohiostate.edu/workshop/）。本次研讨会提供了 来自世界各地约 20 名参与者（高中教师、本科生、博士生、博士后和初级教员）的实践经验与该领域领导者的讲座相结合。这些教育举措极大地补充了 ABRC 持续且高度重视的社区服务使命，从而提高了我们年轻一代对拟南芥和一般植物的认识。由各部门共同资助 分子和细胞生物科学、综合有机体系统和生物基础设施。