CAREER: Hippocampal and prefrontal mechanisms underlying the temporal context of episodic memory

职业：情景记忆时间背景下的海马和前额叶机制

• 批准号: 1150292
• 负责人: Norbert Fortin
• 金额: $ 72.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1150292&HistoricalAwards=false
• 关键词: CAREER; Hippocampal; prefrontal; mechanisms; underlying

Across the animal kingdom, episodic memory is a remarkable and highly adaptive ability. Episodic memory refers to the capacity to remember the events in one's life, including details about the specific location and time in which each experience occurred. Although it has been extensively studied, the brain basis of episodic memory remains poorly understood. This project addresses this important issue using a rodent model of episodic memory that focuses on the capacity to remember "when" specific events occurred (i.e., the order of events in a sequence and the time elapsed since an event occurred). More specifically, this project focuses on characterizing the role of the hippocampus and prefrontal cortex using high-precision techniques, such as localized brain inactivation and recording the electrical properties of single brain cells while rats are engaged in memory tasks. This project will identify the distinct roles that the hippocampus and the prefrontal cortex play in remembering when specific events occurred. Furthermore, the results will also likely shed light on how the two brain structures interact during information processing. A concurrent objective of this project is to develop effective educational practices and materials to promote early science training and awareness in groups underrepresented in science, and to support the development of young scientists in the laboratory and classroom. All developed educational tools will be openly shared on the lab website (http://fortinlab.bio.uci.edu) as well as online repositories of educational information such as Multimedia Educational Resource for Learning and Online Teaching (merlot.org) and OER Commons (oercommons.org).

在整个动物界，情节记忆是一种非凡的高度适应能力。情节记忆指的是记忆一个人生活中的事件的能力，包括每一次经历发生的具体地点和时间的细节。尽管人们对它进行了广泛的研究，但对情节记忆的大脑基础仍然知之甚少。这个项目使用啮齿动物的情节记忆模型来解决这一重要问题，该模型侧重于记忆特定事件发生的时间(即，事件在序列中的顺序和事件发生后经过的时间)的能力。更具体地说，这个项目专注于使用高精度技术来表征海马体和前额叶皮质的作用，例如局部大脑失活，并记录大鼠在进行记忆任务时单个脑细胞的电特性。这个项目将确定海马体和前额叶皮质在记忆特定事件发生时所扮演的不同角色。此外，研究结果还可能有助于揭示这两个大脑结构在信息处理过程中是如何相互作用的。该项目的同时目标是制定有效的教育做法和材料，以促进在科学方面代表性不足的群体进行早期科学培训和提高认识，并支持青年科学家在实验室和课堂上的发展。所有开发的教育工具将在实验室网站(http://fortinlab.bio.uci.edu))以及教育信息的在线储存库，如多媒体学习和在线教学资源(merlot.org)和开放式教育资源共享(oerCommons.org)上公开分享。