Rare-earth-DNA-nanotube complexes for bio-sensing applications

用于生物传感应用的稀土-DNA-纳米管复合物

• 批准号: 1202398
• 负责人: Slava Rotkin
• 金额: $ 36万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1202398&HistoricalAwards=false
• 关键词: Rare; earth; DNA; nanotube; complexes

This project will study near-field optics of nanoscale complexes of rare earth ions with DNA-wrapped nanotubes for bio-sensing applications. A new class of rare earth based bio-compatible materials will be explored. In these materials DNA-wrapped nanotube, functionalized with bio-analytes for optical sensing, will serve as a plasmonic nano-antenna. The approach is to apply a theoretical modeling along with an optical characterization, to understand the near-field interaction between nanotube plasmonic modes and rare-earth emitter in the presence of surrounding bio-molecules. The intellectual merit is in understanding the physics of the near-field electromagnetic modes in the rare-earth/DNA/nanotube complexes, developing schemes for their bio-functionalization and exploring effects of surrounding environment on their near-field response. This will lead to developing new nano-materials and optimizing it for bio-sensor applications on a long run. The broader impact will include dissemination of accumulated fundamental knowledge to undergraduate and graduate students at Lehigh University as well as to students from other PA Schools via the web-based inter-university network MatPAC. Research results will be disseminated to local industry, via the Lehigh Nanotech Network, and to other Lehigh part¬ners from industry, national labs and academia. The K-12 outreach program will include lectures at local schools in Lehigh Valley and contributions to the exhibition at the National facility ? DaVinci Discovery Center. STEM enhancement programs are planned for teachers from local Community Colleges and Kutztown University. Research will benefit the REU and GAAN programs of the Physics Department, with special attention paid to strong involvement from STEM-under¬rep¬re¬sen¬ted groups.

该项目将研究稀土离子的近场光学元件，其中包含DNA包裹的纳米管用于生物传感应用。将探索一类新的基于稀土的生物兼容材料。在这些材料中，DNA包裹的纳米管，用生物分析仪进行光学传感，将用作塑料纳米 - 安坦。该方法是应用理论建模以及光学表征，以了解纳米管等离子体模式与稀土发射极之间的近场相互作用。智力的优点在于理解稀土/DNA/纳米管复合物中近场电子模式的物理学，为其生物官能化和探索周围环境对其近场响应的影响开发了方案。这将导致开发新的纳米材料并长期为生物传感器应用进行优化。广播公司的影响将包括传播利哈伊大学本科生和研究生的累积基本知识，以及通过基于Web的大学间网络MATPAC向其他PA学校的学生传播。研究结果将通过Lehigh Nanotech网络以及工业，国家实验室和学术界的其他Lehigh Parts -Parts分发到本地工业。 K-12外展计划将包括在利哈伊河谷的当地学校的讲座以及国家设施展览的贡献？达芬奇发现中心。 STEM增强计划计划针对当地社区大学和库兹敦大学的教师。研究将使物理部门的REU和GAAN计划受益，并特别注意来自词干范围内的群体的强烈参与。