Structure-Function Design Strategies for Bio-enabled Materials Systems

ID：MPS/DMR/BMAT(7623)1202832 PI：Dillen，J.A.ORG：材料研究会标题：2012年春季MRS研讨会OO：生物使能材料系统的结构-功能设计策略智力优点：本次研讨会将在材料研究会(MRS)2012年春季会议的背景下举行，重点是开发新的策略来设计和构建适用于广泛生物相关功能的新型材料。这是以生物材料为主题的11个预定研讨会之一。已在以下主题领域征集了摘要：(1)肽、寡核苷酸或病毒介导的组装或沉淀，(2)用于特定靶向的基于肽或寡核苷酸的适体，(3)作为治疗或诊断载体的3D细胞模拟，(4)2D配体功能化的SAMS或双层，以及(5)分层结构的生物材料。这些方法适用于可用于基因和药物输送的材料的开发，可用于生物传感或生物激活的自组装纳米阵列的开发，可用于治疗或诊断应用的细胞模拟物的开发，以及可用于支持组织培养或抑制细菌定植或蛋白质沉积造成的污染的功能化表面和基质的开发。这些策略所涉及的挑战包括成功地将非生物材料与生物大分子、细胞成分或细胞模拟物连接以实现所需的功能。这些生物启发或生物使能的杂交材料的成功实现往往源于不同组分之间的特定关联，这些关联实现了独特的协同行为，如受控沉淀事件、精确的图案形成或基于分子识别的组装。最近成功的例子包括多肽驱动的无机颗粒成核，有机和无机成分的自发组织形成纳米复合材料，以及自组装单分子膜或双分子膜促进材料表面的细胞活性。研讨会将为更年轻和更成熟的科学家提供机会，从领先的实践者那里了解最新发展。

ID: MPS/DMR/BMAT(7623) 1202832 PI: Dillen, J. A. ORG: Materials Research SocietyTitle: Spring 2012 MRS Symposium OO: Structure-Function Design Strategies for Bio-Enabled Materials Systems INTELLECTUAL MERIT: This symposium, to be held in the context of the 2012 Spring Meeting of the Materials Research Society (MRS), will focus on developing novel strategies to design and construct novel materials useful for a broad range of biologically relevant functions. It is one of eleven scheduled symposia with a bioimaterials theme. Abstracts have been solicited in the following topic areas: (1) peptide, oligonucleotide, or virus-mediated assembly or precipitation, (2) peptide or oliogonucleotide-based aptamers for specific targeting, (3) 3D cellular mimics as therapeutic or diagnostic vehicles, (4) 2D ligand-functionalized SAMS or bilayers, and (5) hierarchically structured biomaterials. These approaches are appropriate for development of materials that may be employed for gene and drug delivery, of self-assembled nanoscopic arrays that may be used for biosensing or bioactivation, of cellular mimics that may have therapeutic or diagnostic applications, and of functionalized surfaces and matrices that may be used to support tissue culture or to suppress bacterial colonization or fouling by protein deposition.BROADER IMPACTS: Recently, bio-enabled strategies in which biological components are incorporated into otherwise abiological systems, have proven powerful approaches to obtaining intricate hierarchical structures with unique properties that are not otherwise accessible. The challenges involved in these strategies include successfully interfacing nonbiological materials with biomacromolecules, cellular components, or cellular mimics to achieve the desired function. Successful realization of these bio-inspired or bio-enabled hybrid materials often stems from specific associations between heterogeneous components that enable unique synergistic behavior such as controlled precipitation events, precise pattern formation, or molecular recognition-based assembly. Recent successful examples include peptide-driven nucleation of inorganic particles, spontaneous organization of organic and inorganic components to form nanocomposites, and self-assembled monolayers or bilayers to promote cellular activity on a material surface. The symposium will provide opportunities for younger and more established scientists to learn of recent developments from the leading practitioners.