Mechanisms of gene regulation - structure, function and design

基因调控机制——结构、功能和设计

• 批准号: nhmrc : GNT1058916
• 负责人: Prof Joel Mackay
• 金额: $ 66.45万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-gene-regulation-function-design/1344661
• 关键词: Mechanisms; gene; regulation; structure; function

The human genome contains at least 20000 genes. The activity of these genes must be tightly controlled throughout an individual’s life and problems with the regulation of genes lie at the heart of many common and serious diseases, including most forms of cancer. My program of research is focused on understanding the mechanisms underlying gene regulation and on the design of new reagents that could be used to manipulate the activity of genes that behave aberrantly in disease states.

人类基因组至少包含20000个基因。这些基因的活性必须在个体的一生中受到严格控制，基因调控问题是许多常见和严重疾病（包括大多数癌症）的核心。我的研究计划侧重于了解基因调控的机制以及设计可用于操纵在疾病状态下表现异常的基因的活性的新试剂。