Development of In Vivo Marine Magnetic Spectral Resonance Imaging (MMSRI) Capabilities

北卡罗来纳州立大学海洋科学与技术中心(CMAST)获得拨款，用于建造专用空间，以容纳大口径研究磁共振成像和光谱分析(MRI/S)磁体的运行，该磁体采用先进的梯度线圈和垫片进行升级。这种类型的资源目前在美国是不可用的，因此这将是美国唯一专门用于海洋生物研究的大口径高场磁铁。在海洋科学家、核磁共振成像和生物化学工程师、生物学家和生物化学家组成的跨学科小组的支持下，大口径仪器的沿海位置将使其有可能将先进的MMR/IS方法应用于营养水平比以前更高的基础和应用海洋生物学研究的新领域。新设施将使人们能够使用复杂的磁共振成像/S技术，包括InterLeave 13C/31P CSI，以量化活的海洋生物的正常生化功能，并在生化水平上研究环境应激源的影响，以更好地了解气候变化和海洋酸化对海洋生物的影响。大口径仪器将促进新陈代谢通量的研究，从而能够评估多种应激源对海洋生物生理反应的影响，并预测种群、社区和生态系统一级的影响。新设施研究极端海洋环境的生化适应能力，除了阐明海鲜质量和最佳利用的化学基础外，还提供了一个机会来确定新的生理适应和进化的关键途径，以促进海洋资源的保护。中央海洋科学研究中心新的先进磁共振设施将为专注于海岸和海洋问题的不同的科学家、工程师以及研究生和本科生提供更多获得磁共振/S工具的机会，利用中央海洋科学研究中心的教学和研究资源，使广泛的跨学科研究成为可能。附近由NCSU、北卡罗来纳大学、杜克大学和NOAA运营的四个主要海洋实验室的科学家可以很容易地访问新设施，并向国内外客座科学家开放。理科本科生将有机会加入使用该仪器的研究团队，通过CMAST暑期实习生计划、梅里亚暑期研究学者计划以及由NCSU本科生研究计划办公室支持的计划，通过他们在大学范围内指导本科生进行科学研究的计划。欲了解更多有关CMAST的信息，请访问www.cmast.ncsu.edu。

North Carolina State University's Center for Marine Sciences and Technology (CMAST) is awarded a grant to construct dedicated space to accommodate operation of a wide bore research Magnetic Resonance Imaging and Spectroscopy (MRI/S) magnet upgraded with advanced gradient coils and shims. This type of resource is currently unavailable in the U.S. so this will be the only large bore high field magnet dedicated to the study of marine organisms in the country. The coastal location of the wide bore instrument, supported by a cross-disciplinary team of marine scientists, MRI and biochemical engineers, biologists and biochemists, will make it possible to apply advanced MMR/IS methods to new areas of basic and applied marine biology research at higher trophic levels than previously feasible. The new facility will enable the use of complex MRI/S techniques, including inter-leave 13C/31P CSI, to quantify normal biochemical function in living marine organisms and to study the effects of environmental stressors at a biochemical level to better understand impacts of climate change and ocean acidification on marine organisms. The large bore instrument will facilitate studies of metabolic flux, allowing evaluation of the impact of multiple stressors on physiological responses of marine organisms, and prediction of impacts at population, community and ecosystem levels. The capabilities of the new facility to investigate biochemical adaptations to extreme marine environments also offers an opportunity to identify novel physiological adaptations and key pathways in evolution in addition to elucidating the chemical basis of seafood quality and optimal utilization to contribute to the conservation of marine resources.The new advanced magnetic resonance facility at CMAST will improve access to MRI/S tools for a diverse workforce of scientists, engineers, and graduate and undergraduate students focused on coastal and marine questions, leveraging the teaching and research resources of CMAST to enable broad cross disciplinary studies. The new facility will be easily accessible to scientists at four major nearby marine laboratories operated by NCSU, UNC, Duke University, and NOAA, and available for guest scientists domestically and internationally. Undergraduate science students will have opportunities to join research teams using the instrument through and the CMAST summer intern program, the Merial Summer Research Scholars Program, and programs supported by the NCSU Office of Undergraduate Research Programs through their university wide initiatives to mentor undergraduate men and women in science research. More information about CMAST can be found at: www.cmast.ncsu.edu.