Development of In Vivo Marine Magnetic Spectral Resonance Imaging (MMSRI) Capabilities

体内海洋磁共振成像 (MMSRI) 能力的开发

• 批准号: 1227103
• 负责人: David Eggleston
• 金额: $ 33.26万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1227103&HistoricalAwards=false
• 关键词: Development; Vivo; Marine; Magnetic; Spectral

North Carolina State University's Center for Marine Sciences and Technology (CMAST) is awarded a grant to construct dedicated space to accommodate operation of a wide bore research Magnetic Resonance Imaging and Spectroscopy (MRI/S) magnet upgraded with advanced gradient coils and shims. This type of resource is currently unavailable in the U.S. so this will be the only large bore high field magnet dedicated to the study of marine organisms in the country. The coastal location of the wide bore instrument, supported by a cross-disciplinary team of marine scientists, MRI and biochemical engineers, biologists and biochemists, will make it possible to apply advanced MMR/IS methods to new areas of basic and applied marine biology research at higher trophic levels than previously feasible. The new facility will enable the use of complex MRI/S techniques, including inter-leave 13C/31P CSI, to quantify normal biochemical function in living marine organisms and to study the effects of environmental stressors at a biochemical level to better understand impacts of climate change and ocean acidification on marine organisms. The large bore instrument will facilitate studies of metabolic flux, allowing evaluation of the impact of multiple stressors on physiological responses of marine organisms, and prediction of impacts at population, community and ecosystem levels. The capabilities of the new facility to investigate biochemical adaptations to extreme marine environments also offers an opportunity to identify novel physiological adaptations and key pathways in evolution in addition to elucidating the chemical basis of seafood quality and optimal utilization to contribute to the conservation of marine resources.The new advanced magnetic resonance facility at CMAST will improve access to MRI/S tools for a diverse workforce of scientists, engineers, and graduate and undergraduate students focused on coastal and marine questions, leveraging the teaching and research resources of CMAST to enable broad cross disciplinary studies. The new facility will be easily accessible to scientists at four major nearby marine laboratories operated by NCSU, UNC, Duke University, and NOAA, and available for guest scientists domestically and internationally. Undergraduate science students will have opportunities to join research teams using the instrument through and the CMAST summer intern program, the Merial Summer Research Scholars Program, and programs supported by the NCSU Office of Undergraduate Research Programs through their university wide initiatives to mentor undergraduate men and women in science research. More information about CMAST can be found at: www.cmast.ncsu.edu.

北卡罗莱纳州立大学海洋科学与技术中心（CMAST）获得了一笔拨款，用于建造专用空间，以容纳使用先进梯度线圈和垫片升级的大口径研究磁共振成像和光谱（MRI/S）磁铁的操作。这种类型的资源目前在美国是不可用的，所以这将是唯一的大口径高场磁体，专门用于研究海洋生物在该国。在海洋科学家、核磁共振和生物化学工程师、生物学家和生物化学家组成的跨学科小组的支持下，宽孔仪器的沿海位置将有可能将先进的MMR/IS方法应用于比以前可行的更高营养水平的基础和应用海洋生物学研究的新领域。新设施将使用复杂的MRI/S技术，包括13C/31P CSI，量化海洋生物的正常生化功能，并在生化水平上研究环境压力源的影响，以更好地了解气候变化和海洋酸化对海洋生物的影响。大口径仪器将促进代谢通量的研究，评价多种压力源对海洋生物生理反应的影响，并预测对种群、群落和生态系统的影响。除了阐明海产品品质的化学基础和最佳利用之外，新设施研究极端海洋环境的生化适应能力也为确定新的生理适应和进化的关键途径提供了机会，从而为海洋资源的保护做出贡献。CMAST新的先进磁共振设备将为科学家、工程师、专注于沿海和海洋问题的研究生和本科生提供MRI/S工具，利用CMAST的教学和研究资源，实现广泛的跨学科研究。新设施将方便NCSU、北卡罗来纳大学、杜克大学和NOAA运营的附近四个主要海洋实验室的科学家使用，并可供国内外的客座科学家使用。理科生将有机会通过CMAST暑期实习项目、梅里亚暑期研究学者项目和NCSU本科生研究项目办公室支持的项目加入使用该仪器的研究团队，通过他们在全校范围内的倡议指导本科生和本科生进行科学研究。更多关于cmass的信息可以在www.cmast.ncsu.edu上找到。